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Oncología pediátrica

Líneas de investigación

Histiocitosis. Histiocitosis de células de langerhans - linfohistiocitosis hemofagocítica - síndromes hemofagocíticos - enfermedades raras.
Respuesta inmune. Respuesta inflamatoria - células dendríticas - células natural killer - inmunodeficiencias - inmunoterapia en cáncer - sepsis grave - sepsis con fallo multiorgánico.
Tumores cerebrales. PNET/Meduloblastoma y Gliomas.
Agregación familiar al cáncer.
Tumor de Wilms y genes contiguos.
Desarrollo de la seroteca y biobanco de tumores.
Leucemias Linfoblásticas Agudas (Farmacogenética).

Foto grupo

Actividades del grupo

Las actividades de investigación se han centrado en un grupo de enfermedades raras denominadas histiocitosis. Bajo este término se incluye un grupo heterogéneo de enfermedades de causa desconocida consideradas como neoplasias, inmunodeficiencias o malignas. Se caracterizan por la proliferación de células del sistema mononuclear fagocítico (monocitos, macrófagos o células dendríticas) que afecta a diferentes órganos y tejidos. Las formas más frecuentes en la edad pediátrica son la histiocitosis de células de Langerhans (HCL) y la linfohistiocitosis hemofagocítica (HLH).

Los trabajos sobre histiocitosis de células de Langerhans se han centrado en estudios epidemiológicos como la realización de un registro y base de datos de los casos pediátricos en España en colaboración con la Asociación Española contra la Histiocitosis (ACHE) y la Sociedad Española de Hematología y Oncología Pediátricas (SEHOP). Además destaca la coordinación de la participación en ensayos clínicos internacionales de tratamiento de la Histiocyte Society (LCH-III, LCH-IV) desde 2003. Entre los años 2008 y 2011 hemos liderado una parte del proyecto EuroHistioNet para la creación de "A reference network for Langerhans Cell Histiocytosis and histiocytic syndromes" con la creación de una web con contenidos sobre estas enfermedades en varios idiomas incluyendo el castellano, guías de manejo y tratamiento dirigidas tanto a profesionales sanitarios, como al público en general. Este grupo investigador planea continuar sus estudios sobre este grupo de enfermedades y ha presentado una nueva propuesta europea al 7º Programa Marco titulada "Improve clinical practice in the management of histiocytosis patients" (TREAT HISTIO) en 2011. Los recientes descubrimientos sobre el origen de las células de Langerhans patológicas, la proliferación clonal y los mecanismos de producción de citocinas e infiltración orgánica pueden ser útiles también para mejorar el conocimiento de la patogenia de las histiocitosis y buscar nuevas alternativas terapéuticas. Los resultados se podrían aplicar a otras enfermedades caracterizadas por alteraciones de la regulación de las células dendríticas y de las células mieloides, como ocurre en algunos tumores malignos.

La investigación en la Linfohistiocitosis hemofagocítica (HLH) se centró inicialmente en colaborar en el desarrollo un nuevo protocolo de tratamiento mundial de la Histiocyte Society (HLH-2004) e implantar estas recomendaciones internacionales en España. Después se creó una red entre varios hospitales españoles para mejorar la detección de los casos hereditarios o familiares y las formas secundarias en España, gracias a un proyecto financiado en 2008 en una convocatoria de BIOEF sobre enfermedades raras. Los estudios iniciales de HLH fueron epidemiológicos, pero desde 2009 los proyectos incluyen estudios de laboratorio para buscar nuevas herramientas diagnósticas y biomarcadores en los síndromes hemofagocíticos. Dado que esta enfermedad se considera una inmunodeficiencia primaria y se caracteriza por una respuesta inflamatoria excesiva causada por una proliferación incontrolada de linfocitos activados e histiocitos que secretan gran cantidad de citocinas, los descubrimientos sobre los defectos en los mecanismos reguladores de la respuesta inmune e inflamatoria y en el control de la proliferación y destrucción celular, pueden ser aplicables a otras enfermedades graves como las sepsis con fallo multiorgánico y otros síndromes hiperinflamatorios. En los proyectos vigentes en 2011 y 2012 se estudiarán estas alteraciones tanto en HLH como en sepsis graves de pacientes pediátricos y adultos.
 En la mayoría de los pacientes con HLH, se observan alteraciones en la función de las células natural killer (NK) y elevación de los niveles de diversas citoquinas proinflamatorias. Estas mismas alteraciones se observan también en algunos pacientes con cáncer que sufren defectos en los mecanismos de linfocitotoxicidad. Para desarrollar esta línea de investigación del papel de la Inmunoterapia con células NK en el cáncer infantil hemos presentado un proyecto a una convocatoria reciente de la Asociación Española Contra el Cáncer, en colaboración con el Hospital Niño Jesús y otras unidades de oncología pediátrica españolas.

Las histiocitosis tienen una historia natural muy variable y son frecuentes las reactivaciones. Además pueden originar secuelas importantes como déficits hormonales y problemas neurológicos. Existe una preocupación creciente sobre la calidad de vida de los supervivientes. Para ello trabajamos a nivel local en colaboración con la Universidad de Deusto para desarrollar herramientas de apoyo psicoemocional para pacientes con enfermedades raras (proyecto BIZKAIALAB) de la Diputación de Bizkaia. Además participamos en un proyecto internacional de DG Sanco denominado BURQOL, que trata de medir el impacto socioeconómico y la calidad de vida relacionada con la salud en 10 enfermedades raras, entre las que se incluyen las histiocitosis (2010-2013).

En la Unidad de Hematología y Oncología Pediátrica del Hospital Universitario de Cruces se viene desarrollando investigación clínica en tumores y leucemias infantiles desde 1992, con dedicación prioritaria al estudio de los tumores cerebrales, ya que la jefa de la Unidad fue nombrada coordinadora nacional del grupo de trabajo de tumores cerebrales de la Sociedad Española de Hematología y Oncología Pediátricas (SEHOP) ese mismo año. A su vez se implicó en los ensayos multicéntricos multinacionales de la Sociedad Internacional de Oncología Pediátrica (SIOP), y comenzó así, a crear la infraestructura de investigación básica aplicada a la clínica. Se han puesto a punto las técnicas de biología molecular de meduloblastomas y gliomas. Se han difundido los protocolos de recogida y envío y procesamiento de muestras a todos los hospitales colaboradores implicados a nivel nacional, dado que el hospital de Cruces ha centralizado los estudios moleculares e inmuno-histoquímicos, obligatorios para la inclusión de pacientes en futuros ensayos clínicos. Para ello y de acuerdo con la normativa validada en el SIOP Brain tumor Group, los investigadores del grupo (oncólogos y biólogos) han participado en numerosas reuniones presenciales y teleconferencias programadas periódicamente. Se están realizando determinaciones de marcadores genéticos en otros tumores sólidos pediátricos (sarcoma de Ewing y tumor de Wilms) con la colaboración del departamento de anatomía patológica.

La puesta a punto de la expresión del TP53 en los estudios de agregación familiar al cáncer se sigue realizando en todos los casos solicitados y se están ampliando los estudios de marcadores moleculares en otros síndromes pediátricoscon riesgo aumentado de predisposición al desarrollo de tumores sólidos y leucemias

Como consecuencia de toda la actividad realizada en años previos se ha proseguido incrementando la seroteca, el biobanco de tumores y las muestras obtenidas de líquido cefalorraquideo de los pacientes diagnosticados de cáncer.
En colaboración con el departamento de Genética, Antropología Física y Fisiología Animal de la UPV, se están realizando estudios de farmacogenética en leucemias y linfomas infantiles motivo de varias publicaciones y de utilidad aplicada a la clínica.

En colaboración con el CNIO y con la Universidad de Navarra se están realizando estudios de otros marcadores genéticos de riesgo en leucemias y tumores óseos.

Mantenemos la colaboración con el Centro Superior del Instituto del Cáncer dependiente de la Universidad Autónoma de Madrid para estudios moleculares protocolizados de Sarcoma de Ewing y Retinoblastomas, con la Universidad de Valencia para estudios moleculares en Neuroblastomas y con la Autónoma de Barcelona para estudios de Sarcomas de partes blandas.

Nuestras líneas de investigación se han ido desarrollando con financiación pública, gracias a la obtención de proyectos financiados por el FIS, proyectos de Redes Temáticas del Ministerio de Sanidad y Consumo, proyectos de la Universidad del País Vasco, ya que la investigadora principal es profesora titular del departamento de Pediatría de la Facultad de Medicina de dicha Universidad, y proyectos del departamento de Sanidad del Gobierno Vasco por su vinculación como jefe clínico asistencial del Hospital Universitario Cruces.

Además ha formado parte y sigue participando en líneas asociadas a la investigación en tumores sólidos y leucemias como colaborador externo en otros proyectos tanto en ámbito nacional como internacional, formando parte de comités de trabajo e incluyendo datos clínicos y datos de pacientes. Dichos proyectos son de financiación pública y privada.

Coordinador/a del grupo



Miembros del grupo

  Ricardo López Almaraz
 
 
  Idoia Martín Guerrero
 
  Maria Jose Lopez De La Serna
 
 
  Aizpea Beatriz Echebarria Barona
 
 
  Susana Garcia Obregon
 
  |   842456
  María Angeles Gil Lemus
 
 
  Lide Alaña Rodrigo
 
  |   842401
  Iratxe Seijas Betolaza
 
 
  Rosa María Adan Pedroso
 
 
  Elixabet López López
 
  Laura Zaldumbide Dueñas
 
 
  Miguel Alejandro García Ariza
 
 
  Margarita Díez De Fuentes
 
 
  Marta Menchaca Torio
 
 
  Ángela Gutiérrez Camino
 
  Olatz Villate Bejarano
 
  |   847247
  Estíbaliz Solorzano Rodríguez
 
 
  Jimena María De Pedro Olabarri
 
 
  Piedad Alba Pavón
 
  |   842456
  María Pilar Martín Lucas
 
 
  Gloria Chocarro Amatriain
 
 
  María Carmen Marcos Pérez
 
 
  María Esther Benito Serrano
 
 
  Ruth Nocedal Bañuelos
 
 
  Paula González Urdiales
 
 
  Irati Rekondo Izaguirre
 
  |   847247
  Teresa Mercedes Cardenal Alonso-Allende
 
 
  Nerea Bilbao Aldaiturriaga
 
 
  Miriam Sánchez Sáez
 
 

Publicaciones del grupo

ASTIGARRAGA I, Guerra E, Garcia Obregon S, Pocheville I, Roman L. Congenital Syphilis May Mimic Hemophagocytic Lymphohistiocytosis and Should be Ruled Out in Newborns. Pediatr Blood Cancer. 2022; 69: 1-2

Tagarro A, Cobos Carrascosa E, Villaverde S, Sanz Santaeufemia FJ, Grasa C, Soriano Arandes A, et al. Clinical spectrum of COVID-19 and risk factors associated with severity in Spanish children. Eur J Pediatr. 2022; 181(3): 1105-1115. DOI:10.1007/s00431-021-04306-6.

Alana L, Nunes Xavier CE, Zaldumbide L, Martin Guerrero I, Mosteiro L, Alba Pavon P, et al. Identification and Functional Analysis of a Novel CTNNB1 Mutation in Pediatric Medulloblastoma. Cancers (Basel). 2022; 14(2). DOI:10.3390/cancers14020421.

Villate O, Maortua H, Tejada M, Llano Rivas I. RNA Analysis and Clinical Characterization of a Novel Splice Variant in the NSD1 Gene Causing Familial Sotos Syndrome. Front Pediatr. 2022; 10. DOI:10.3389/fped.2022.827802.

Brigitha LJ, Fiocco M, Pieters R, Albertsen BK, Escherich G, Lopez E, et al. Hypersensitivity to Pegylated E.coli asparaginase as first-line treatment in contemporary paediatric acute lymphoblastic leukaemia protocols: a meta-analysis of the Ponte di Legno Toxicity working group. Eur J Cancer. 2022; 162. DOI:10.1016/j.ejca.2021.11.016.

Pilar Orive FJ, Astigarraga I, Azkargorta M, Elortza F, Garcia Obregon S. A Three-Protein Panel to Support the Diagnosis of Sepsis in Children. J Clin Med. 2022; 11(6). DOI:10.3390/jcm11061563.

Saenz de Urturi D, Buque X, Porteiro B, Folgueira C, Mora A, Delgado TC, et al. Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis. Nat Commun. 2022; 13(1): 1096-1096. DOI:10.1038/s41467-022-28749-z.

Galiacho VR, Pomposo MP, Echebarria Barona A, Urdiales PG, Ruiz JCG. Appearances are deceiving: immature lymphocytes in Leishmaniasis. Blood Res. 2022; 57(1): 4-4. DOI:10.5045/br.2022.2021191.

Helenius M, Vaitkeviciene G, Abrahamsson J, Jonsson OG, Lund B, Harila Saari A, et al. Characteristics of white blood cell count in acute lymphoblastic leukemia: A COST LEGEND phenotype-genotype study. Pediatr Blood Cancer. 2022; 69(6). DOI:10.1002/pbc.29582.

Illarregi U, Telleria J, Bilbao Aldaiturriaga N, Lopez E, Ballesteros J, Martin Guerrero I, et al. lncRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review. Int J Oncol. 2022; 60(5). DOI:10.3892/ijo.2022.5348.

Albert Mari A, Jimenez Pulido I, Jose Ruiz BS, Conde Estevez D, Gil Lemus MA, Cercos Lleti AC, et al. Antineoplastic extravasation management: Consensus of the Spanish Oncology Pharmacy Group (GEDEFO). J Oncol Pharm Pract. 2022. DOI:10.1177/10781552221091914.

Pineiro Perez R, Nunez Cuadros E, Cabrera Garcia L, Diez Lopez I, Escrig Fernandez R, Gil Lemus MA, et al. Results of a national survey on knowledge and use of complementary and alternative medicine by paediatricians. An Pediatr (Engl Ed). 2022; 96(1). DOI:10.1016/j.anpede.2020.09.012.

Casas A, Ciruelos E, Oliveira M, Saura C, Bellet M, Pernas S, et al. Solti-1903 HOPE: Real-world clinical practice study to assess the impact of using genomic data on the next treatment decision making-choice in patients with locally advanced or metastatic breast cancer in Spain. Cancer Res. 2022; 82(4). DOI:10.1158/1538-7445.SABCS21-OT2-06-01.

Solsona M, Berrueco R, Sebastian E, Cervera A, Sastre A, ASTIGARRAGA I, et al. Tapering of the thrombopoietin receptor agonist in paediatric patients with chronic immune thrombocytopenia: Is it possible?. Br J Clin Pharmacol. 2022; 88(9): 4220-4223. DOI:10.1111/bcp.15378.

Udondo Gonzalez Del Tanago B, Aguirre Menica M, Zaldumbide Duenas L, Martinez Exposito O, Gonzalez Hermosa MR. Hundreds of vasculoproliferative skin lesions in a paediatric renal transplant recipient. Clin Exp Dermatol. 2022; 47(9): 1748-1751. DOI:10.1111/ced.15234.

Roldan Galiacho V, Lopez Almaraz R, Zaldumbide Duenas L, Garcia Ruiz JC. Alveolar rhabdomyosarcoma with cannibalism and erythroid leukaemia-like morphology. Int J Lab Hematol. 2022. DOI:10.1111/ijlh.13911.

Reparaz P, Serrano I, Adan Pedroso R, Astigarraga I, de Pedro Olabarri J, Echebarria Barona A, et al. Clinical management of the acute complications of sickle cell anemia: 11 years of experience in a tertiary hospital. An Pediatr (Engl Ed). 2022. DOI:10.1016/j.anpede.2022.06.002.

Gallego Perez Larraya J, Garcia Moure M, Labiano S, Patino Garcia A, Dobbs J, Gonzalez Huarriz M, et al. Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma. N Engl J Med. 2022; 386(26): 2471-2481. DOI:10.1056/NEJMoa2202028.

Gargallo P, Bautista F, Juan Ribelles A, Izquierdo E, Soriano A, de Rojas T, et al. Current status of precision medicine in pediatric oncology in Spain: a consensus report by the Spanish Society of Paediatric Haematology and Oncology (SEHOP). Clin Transl Oncol. 2022; 24(5): 809-815. DOI:10.1007/s12094-021-02759-7.

Astigarraga I, Garcia Obregon S, Perez Martinez A, Gutierrez Carrasco I, Santa Maria V, Iturrate CR, et al. Langerhans cell histiocytosis. Advances in pathogenesis and clinical practice. An Pediatr (Engl Ed). 2022; 97(2): 1301-1307. DOI:10.1016/j.anpede.2022.05.005.

Roldan Galiacho V, Zaldumbide Duenas L, Lobo Olmedo A, Alonso Varela M, Garcia Ruiz JC. Intracytoplasmic crystalline inclusions in peripheral blood lymphocytes in small lymphocytic lymphoma. Br J Haematol. 2022; 199(1): 8-8. DOI:10.1111/bjh.18380.

Salmerón Villalobos J, Ramis Zaldivar JE, Balagué O, Verdú Amorós J, Celis V, Sábado C, et al. Diverse mutations and structural variations contribute to Notch signaling deregulation in paediatric T-cell lymphoblastic lymphoma. Pediatr Blood Cancer. 2022; 69(11): 29926-29926. DOI:10.1002/pbc.29926.

Alana L, Martin Guerrero I, Navajas A, Zaldumbide L, Mosteiro L, Schwalbe EC, et al. MOLECULAR SUBCLASSIFICATION OF A NATIONAL COHORT OF PEDIATRIC MEDULLOBLASTOMA BASED ON METHYLATION PROFILE. Neuro-Oncology. 2022; 24: 121-121

Goddard J, Castle J, Southworth E, Fletcher A, Crosier S, Martin Guerrero I, et al. MOLECULAR CHARACTERISATION OF GROUP 4 MEDULLOBLASTOMA IMPROVES RISK-STRATIFICATION AND ITS BIOLOGICAL UNDERSTANDING. Neuro-Oncology. 2022; 24: 123-123

Serrano Pejenaute I, Lopez Almaraz R, Echebarria A, Adan R, De Pedro J, Gonzalez P, et al. LIFE AND END-OF-LIFE AFTER DIFFUSE INTRINSIC PONTINE GLIOMA DIAGNOSIS. Neuro-Oncology. 2022; 24: 26-26

Epalza C, Prieto Tato L, Pino R, Escartin Paredes P, Leoz I, Grasa C, et al. Safety and Acceptance of COVID-19 Vaccination After Multisystem Inflammatory Syndrome in Children (MIS-C) in Spain. J Pediatr Infect Dis Soc. 2022; 11(10): 471-473. DOI:10.1093/jpids/piac076.

Buque X, Saenz de Urturi D, Porteiro B, Folgueira C, Mora A, Cardoso Delgado T, et al. Methionine adenosyltransferase 1a antisense oligonucleotides induce the fibroblast growth factor 21-driven recovery from obesity and associated hepatoesteatosis. J Hepatol. 2022; 77: 689-690

Alvarez Martinez L, Ruiz Aja E, Valdivieso Castro MP, Cardenal Alonso Allende TM, Galvez Estevez CM, Galbarriatu Gutierrez A, et al. Common surgical training program: standardization of learning quality. Cir Pediatr. 2022; 35(4): 196-203. DOI:10.54847/cp.2022.04.20.

Rollan Martinez Herrera M, Gonzalez Urdiales P, Zubizarreta Zamalloa A, Rodriguez Merino E, Martinez Dubarbie F. Central nervous system infection by Bacillus cereus: a case report and literature review. Rev Neurologia. 2022; 75(8): 239-245. DOI:10.33588/rn.7508.2021412.

Menchaca M, Astigarraga I, De la Serna MJL, Marcos C, Martin P, Sanz I, et al. IMPLEMENTATION OF A PEDIATRIC EARLY WARNING SYSTEM (PEWS) IN A PEDIATRIC ONCOLOGY UNIT OF A SPANISH HOSPITAL: ADVANTAGES AND LIMITATIONS. Pediatr Blood Cancer. 2022; 69: 548-549

Alba Pavon P, Alana L, Gutierrez Jimeno M, Echebarria Barona A, Imizcoz T, Zaldumbide L, et al. IDENTIFICATION OF POTENTIALLY PATHOGENIC VARIANTS IN CANCER PREDISPOSITION GENES IN PEDIATRIC SARCOMAS BY NEXT GENERATION SEQUENCING. Pediatr Blood Cancer. 2022; 69: 237-238

Adan Pedroso R, De Pedro Olabarri J, Gonzalez Urdiales P, Moreno Diez M, Echebarria Barona A, Garcia Ariza M, et al. PATIENTS WITH RELAPSED ACUTE LYMPHOBLASTIC LEUKEMIA TREATED WITH BLINATUMOMAB AND INOTUZUMAB. EXPERIENCE IN A TERTIARY CARE HOSPITAL. Pediatr Blood Cancer. 2022; 69: 574-574

Astigarraga I, Alba Pavon P, Santa Maria V, Ruano D, Andres M, Valero Arrese L, et al. USE OF MAPK PATHWAY INHIBITORS IN PEDIATRIC HISTIOCYTOSIS IN SPAIN. Pediatr Blood Cancer. 2022; 69: 278-279

Illade L, Garrido C, Cruz O, Garcia Ariza M, Solano Paez P, Llort A, et al. A NATIONAL PEDIATRIC NEURO-ONCOLOGY TUMOR BOARD INITIATIVE IN SPAIN: RESULTS OF A WEB-BASED SURVEY TO EVALUATE PARTICIPANT EXPERIENCE UTILIZING THIS RESOURCE. Pediatr Blood Cancer. 2022; 69: 295-296

Illarregi U, Bilbao Aldaiturriaga N, Jakjimovska A, Gutierrez Camino A, Del Orbe R, Astigarraga I, et al. NEW PROGNOSTIC BIOMARKERS IN ACUTE LYMPHOBLASTIC LEUKEMIA: LONG NON-CODING RNAS. Pediatr Blood Cancer. 2022; 69

Villarroel M, Secchieri N, Jara DC, Fu L, Cordova M, Cuturi B, et al. MULTIDISCIPLINARY TUMOR BOARD FOR THE LATINAMERICAN PEDIATRIC ONCOLOGY GROUP (GALOP) RARE TUMOR INITIATIVE. Pediatr Blood Cancer. 2022; 69: 288-288

Lide A, Aguirre Carrillo JA, Martin Guerrero I, Zaldumbide L, Mosteiro L, Ansede Bermejo J, et al. NATIONAL EXPERIENCE AND USEFULNESS OF CENTRALIZED PATHOLOGICAL AND MOLECULAR REVIEW IN PEDIATRIC MEDULLOBLASTOMA. Pediatr Blood Cancer. 2022; 69: 301-302

Moraleda RG, Zabala LC, Palacio J, De La Serna MJL. THE BALINT GROUP AS A RESOURCE FOR EMOTIONAL CARE IN A PAEDIATRIC ONCOLOGY UNIT OF A TERTIARY HOSPITAL. Pediatr Blood Cancer. 2022; 69: 396-396

Moreno Carrasco JL, Vazquez Gomez F, Baroni L, Alderete D, Mastronuzzi A, Zapotocky M, et al. INTRATUMORAL HEMORRHAGE IN PEDIATRIC LOW-GRADE-GLIOMAS: AN INTERNATIONAL CASE SERIES. Pediatr Blood Cancer. 2022; 69: 300-300

Elbal ER, Sanchez IF, Martinez BG, Adan Pedroso R, Lassaletta A, Valero JMV, et al. ANALYSIS OF THE OUTCOME OF PRE-B STANDARD RISK RELAPSES REGISTERED IN THE SEHOP-PETHEMA 2015 GUIDELINES. Pediatr Blood Cancer. 2022; 69

Elbal ER, Gil MDPG, Martinez BG, Lassaletta A, Sanz J, Adan Pedroso R, et al. CHILDHOOD LATE BONE MARROW RELAPSES IN B CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA IN SPAIN. ANALYSIS OF TREATMENT OUTCOMES. Pediatr Blood Cancer. 2022; 69

Rio P, Sevilla J, Navarro S, Zubicaray J, Sanchez Dominguez R, Nicoletti E, et al. Long-Term Phenotypic Correction of Fanconi Anemia-A Patients Treated by Gene Therapy in Early Stages of the Bone Marrow Failure. Mol Ther. 2022; 30(4): 370-370

Astigarraga I, Ollauri Ibanez C, Garcia Obregon S, Villate O, Alba Pavon P, Belaustegui A et al. HYPERFERRITINEMIA IS A BAD PROGNOSIS FACTOR IN COVID-19 PATIENTS AND IT IS NOT SPECIFIC FOR HLH IN ADULTS. Pediatr Blood Cancer. 2021; 68

Ollauri Ibanez C, Astigarraga I. Use of Antiangiogenic Therapies in Pediatric Solid Tumors. Cancers (Basel). 2021; 13(2). DOI:10.3390/cancers13020253.

Infante A, Gener B, Vazquez M, Olivares N, Arrieta A, Grau G et al. Reiterative infusions of MSCs improve pediatric osteogenesis imperfecta eliciting a pro-osteogenic paracrine response: TERCELOI clinical trial. Clin Transl Med. 2021; 11(1): 265-265. DOI:10.1002/ctm2.265.

Arzuaga Mendez J, Lopez Santillan M, Garcia Ruiz JC, Lopez E, Martin Guerrero I. Systematic Review of the Potential of MicroRNAs in the Management of Patients with Follicular Lymphoma. Crit Rev Oncol Hematol. 2021; 159: 103247-103247. DOI:10.1016/j.critrevonc.2021.103247.

Lopez E, Evans WE. New insights into methotrexate accumulation in leukemia cells in vivo. MOL CELL ONCOL. 2021; 8(1). DOI:10.1080/23723556.2020.1865086.

Iglesias J, C, De la Fuente P, Galbarriatu L, Paternain C, de Gopegui ER et al. Neurenteric CYST of the craniocervical junction. Case report. Interdiscip Neurosurg. 2021; 23. DOI:10.1016/j.inat.2020.100852.

Luis B, Miguel M, Pedro D, David I, Itziar A, Ana G et al. Benefits of early aggressive immunomodulatory therapy (tocilizumab and methylprednisolone) in COVID-19: single center cohort study of 685 patients. J Transl Autoimmun. 2021; 4: 100086-100086. DOI:10.1016/j.jtauto.2021.100086.

Maagdenberg H, Oosterom N, Zanen J, Gemmati D, Windsor RE, Heil SG et al. Genetic variants associated with methotrexate-induced mucositis in cancer treatment: a systematic review and meta-analysis. Crit Rev Oncol Hematol. 2021; 161: 103312-103312. DOI:10.1016/j.critrevonc.2021.103312.

Zenarruzabeitia O, Astarloa Pando G, Terren I, Orrantia A, Perez Garay R, Seijas Betolaza I et al. T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19. Front Immunol. 2021; 12. DOI:10.3389/fimmu.2021.655934.

Garces J, Prieto IS, Zaldumbide Duenas L, Fernandez Ruanova B, Zubizarreta AC, Olabarria IV. Foreign body granuloma as a complication of endovascular treatment of brain aneurysm. Interdiscip Neurosurg. 2021; 24. DOI:10.1016/j.inat.2020.101068.

Villaverde S, Dominguez Rodriguez S, Sabrido G, Perez Jorge C, Plata M, Romero MP et al. Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population. J Pediatr. 2021; 232. DOI:10.1016/j.jpeds.2021.01.027.

Axpe IR, Goni BM, Duenas LZ, Idiondo E. Diagnostic difficulty of a glioblastoma with an unusual presentation. Neurologia. 2021; 36(3): 241-243. DOI:10.1016/j.nrl.2020.04.016.

Delgado Lopez PD, Buzon Martin L, Montero Baladia M, ASTIGARRAGA I. Etoposide for Cytokine Storm Because of Coronavirus Disease 2019. Chest. 2021; 159(4): 1678-1679. DOI:10.1016/j.chest.2020.10.090.

Bisogno G, Sarnacki S, Stachowicz Stencel T, Colin VM, Ferrari A, Godzinski J et al. Pleuropulmonary blastoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations. Pediatr Blood Cancer. 2021; 68: 286-287. DOI:10.1002/pbc.29045.

Schneider DT, Orbach D, Ben Ami T, Bien E, Bisogno G, Brecht IB et al. Consensus recommendations from the EXPeRT/PARTNER groups for the diagnosis and therapy of sex cord stromal tumors in children and adolescents. Pediatr Blood Cancer. 2021; 68: 62-63. DOI:10.1002/pbc.29017.

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Cabezas M, Camos M, Rives S, Garcia Orad A, Lopez E, Dapena JL, et al. Impact of polymorphisms in apoptosis-related genes on the outcome of childhood acute lymphoblastic leukaemia. Br J Haematol. 2019; 185(1): 159-162. DOI:10.1111/bjh.15415.

Astigarraga I, Garcia Obregon S, Alba Pavon P, Seijas I, Pilar Orive J, Borrego F, et al. THE ROLE IN DIAGNOSIS OF HIGH SERUM LEVELS OF sCD25 AND sCD163 IN PATIENTS WITH SEVERE SEPSIS AND HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS (HLH). Pediatr Blood Cancer. 2019; 66(1): 1-1

Blincoe A, Heeg M, Campbell P, Khojah A, Klein Gitelman M, Talano J, et al. Isolated Central Nervous System Disease in Familial Hemophagocytic Lymphohistiocytosis a Multicenter Case Series. J Clin Immunol. 2019; 39(1): 112-113

Angel Garcia Ariza M. A Geometric Approach to the Concept of Extensivity in Thermodynamics. Symmetry Integr Geom. 2019; 15. DOI:10.3842/SIGMA.2019.015.

Martin Guerrero I, Salaverria I, Burkhardt B, Chassagne Clement C, Szczepanowski M, Bens S, et al. Non-leukemic pediatric mixed phenotype acute leukemia/lymphoma: Genomic characterization and clinical outcome in a prospective trial for pediatric lymphoblastic lymphoma. Genes Chromosomes Cancer. 2019; 58(6): 365-372. DOI:10.1002/gcc.22726.

Manzardo C, Londono MC, Castells L, Testillano M, Luis Montero J, Penafiel J, et al. Direct-acting antivirals are effective and safe in HCV/HIV-coinfected liver transplant recipients who experience recurrence of hepatitis C: A prospective nationwide cohort study (vol 18, pg 2513, 2018). Am J Transplant. 2019; 19(2): 614-614. DOI:10.1111/ajt.15244.

Gonzalez Hermosa MR, Guerra E, Tuduri I, Vicente I, Lopez Almaraz R. CLAPO syndrome: Effective response to treatment with oral rapamycin. Dermatol Ther. 2019; 32(4). DOI:10.1111/dth.12991.

Pena Merino L, Lopez Almaraz R, Fernandez de Larrinoa A, Rubio Lombrana M, Rosario Gonzalez Hermosa M. Multifocal lymphangioendotheliomatosis without thrombocytopenia or clinical signs of systemic bleeding. Pediatr Dermatol. 2019; 36(6): 965-966. DOI:10.1111/pde.13959.

Gonzalez Farre B, Enric Ramis Zaldivar J, Salmeron Villalobos J, Balague O, Celis V, Verdu Amoros J, et al. Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma. Haematologica. 2019; 104(9): 1822-1829. DOI:10.3324/haematol.2018.207928.

Embade N, Cannet C, Diercks T, Gil Redondo R, Bruzzone C, Anso S, et al. NMR-based newborn urine screening for optimized detection of inherited errors of metabolism. Sci Rep. 2019; 9(1): 13067-13067. DOI:10.1038/s41598-019-49685-x.

Stucklin ASG, Boue DR, Finlay JL, Coven SL, de Prada I, Perez Somarriba M, et al. Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019; 10(1): 4343-4343. DOI:10.1038/s41467-019-12187-5.

Solorzano E, Chocarro G, Cardenal T, Valdivieso M, Astigarraga I, Garcia Fernandez R, et al. Application of 3D Scanner Reconstructions and Printing for Complex Pediatric Solid Tumors Surgery. Pediatr Blood Cancer. 2019; 66: 499-500

Bilbao Salcines N, Diaz Santaren H, Lopez Almaraz R, Astigarraga I, De Pedro J, Echebarria A, et al. Deep Venous Thrombosis (DVT) in Pediatric Patients Diagnosed with Acute Lymphoblastic Leukemia (ALL). Comparison Between Two National Protocols. Pediatr Blood Cancer. 2019; 66: 573-573

Echebarria Barona A, Bilbao Salcines N, Astigarraga I, Garcia Ariza M, Lopez Almaraz R, De Pedro J, et al. Early and Severe Central Nervous System (CNS) Complications at Diagnosis in Pediatric Patients with Acute Leukemia. Pediatr Blood Cancer. 2019; 66: 276-276

Espinosa A, Lopez Almaraz R, Bilbao Salcines N, Echebarria Barona A, De Pedro J, Garcia Ariza M, et al. Fever Management in High-Risk Neuroblastoma During Immunotherapy. Pediatr Blood Cancer. 2019; 66: 425-425

Collazos Zabala L, Gonzalez Moraleda R, Guadilla Fernandez ML, Iniesta Okariz C, De Pedro Olabarri J. The Symbolization of the Experience of Illness in Children Diagnosed with Cancer. Pediatr Blood Cancer. 2019; 66: 645-646

Alba Pavon P, Astigarraga I, Garcia Obregon S, Echebarria A, Garcia Ariza M, Lopez Almaraz R, et al. Identification of Gardner Syndrome Among Paediatric Fibroblastic and Myofibroblastic Tumours: A Study of 7 Cases. Pediatr Blood Cancer. 2019; 66: 347-348

Beutel K, Horne A, Rao K, Moshous D, Astigarraga I, Elzembely M, et al. Late effects in patients with hemophagocytic lymphohistiocytosis treated with hematopoietic stem cell transplantation: A review of the literature. Bone Marrow Transplant. 2019; 54(1): 546-547

Collazos Zabala L, Lopez de la Serna MJ, Gonzalez Moraleda R, Menchaca Torio M, Astigarraga Aguirre MI. Parent's Support Programme in a Paediatric Oncology Unit of a Tertiary Hospital: ``Coffee with Parents''. Pediatr Blood Cancer. 2019; 66: 645-645

Monteagudo E, Astigarraga I, Cervera A, Angeles Dasi M, Sastre A, Berrueco R, et al. Protocol for the study and treatment of primary immune thrombocytopenia: ITP-2018. An Pediatr. 2019; 91(2). DOI:10.1016/j.anpede.2019.04.008.

Gutierrez Camino A, Umerez M, Santos B, Martin Guerrero I, Lopez E, de Andoin NG, et al. rs2648841 in miR-1208 is involved in hepatotoxicity during consolidation in childhood acute lymphoblastic leukemia treatment. Eur J Hum Genet. 2019; 27(1): 549-549

Chocarro G, Solorzano E, Valdivieso M, Alvarez L, Cardenal TM, Lopez Almaraz R, et al. Surgical Emergencies in Paediatric Cancer at Diagnosis. The Difficulty of Deciding When to Opperate or Not. Pediatr Blood Cancer. 2019; 66: 495-495

Collazos Zabala L, Gonzalez Moraleda R, Lopez de la Serna MJ, Iniesta Okariz C, Guadilla Fernandez ML. The Countertransference of the Health Team in a Paediatric Oncology Unit of a Tertiary Hospital. Pediatr Blood Cancer. 2019; 66: 644-645

Arzuaga Mendez J, Lopez Santillan M, Lopez E, Martin Guerrero I, Amutio Diez E, Garcia Orad A, et al. CLASSIC EVOLUTION OF THE DIFFUSED BIG CELL LYMPHOMA (LDCGB) THROUGH NEXT GENERATION SEQUENCING (NGS), THROUGH THREE CASES. Haematologica. 2019; 104(3): 373-374

Nunes Xavier CE, Aurtenetxe O, Zaldumbide L, Lopez Almaraz R, Erramuzpe A, Cortes JM, et al. Protein tyrosine phosphatase PTPN1 modulates cell growth and associates with poor outcome in human neuroblastoma. Diagn Pathol. 2019; 14(1): 134-134. DOI:10.1186/s13000-019-0919-9.

Herrera Espejo S, Santos Zorrozua B, Alvarez Gonzalez P, Lopez E, Garcia Orad A. A Systematic Review of MicroRNA Expression as Biomarker of Late-Onset Alzheimer's Disease. Mol Neurobiol. 2019; 56(12): 8376-8391. DOI:10.1007/s12035-019-01676-9.

Bautista F, Canete A, Ramirez Villar GL, Fernandez JM, Fuster JL, Diaz de Heredia C, et al. ECLIM-SEHOP, a new platform to set up and develop international academic clinical trials for childhood cancer and blood disorders in Spain. Clin Transl Oncol. 2019; 21(12): 1763-1770. DOI:10.1007/s12094-019-02221-9.

Monteagudo E, Astigarraga I, Cervera Á, Dasí MA, Sastre A, Berrueco R, et al. Protocolo de estudio y tratamiento de la trombocitopenia inmune primaria: PTI-2018. An Pediatr. 2019; 91(2). DOI:10.1016/j.anpedi.2019.04.014.

Villate O, Ibarluzea N, Fraile Bethencourt E, Valenzuela A, Velasco EA, Grozeva D, et al. Functional Analyses of a Novel Splice Variant in the CHD7 Gene, Found by Next Generation Sequencing, Confirm Its Pathogenicity in a Spanish Patient and Diagnose Him with CHARGE Syndrome. Front Genet. 2018; 9(JAN). DOI:10.3389/fgene.2018.00007.

Pereda A, Garin I, Perez de Nanclares G, Anda E, Berrade S, Ramos Arroyo MA, et al. What to consider when pseudohypoparathyroidism is ruled out: iPPSD and differential diagnosis. BMC Med Genet. 2018; 19(1): 32-32. DOI:10.1186/s12881-018-0530-z.

Alvarez Mora MI, Madrigal I, Martinez F, Tejada MI, Izquierdo Alvarez S, de Saz PSV, et al. Clinical implication of FMR1 intermediate alleles in a Spanish population. Clin Genet. 2018; 94(1): 153-158. DOI:10.1111/cge.13257.

Rebbeck TR, Friebel TM, Friedman E, Hamann U, Huo DZ, Kwong A, et al. Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations. Hum Mutat. 2018; 39(5): 593-620. DOI:10.1002/humu.23406.

Aldamiz Echevarria L, Couce ML, Villate O, Fernandez Marmiesse A, Pinan MA. New CTSA mutation in early infantile galactosialidosis. Pediatr Int. 2018; 60(8): 761-762. DOI:10.1111/ped.13604.

Bullich G, Domingo Gallego A, Vargas I, Ruiz P, Lorente Grandoso L, Furlano M, et al. A kidney-disease gene panel allows a comprehensive genetic diagnosis of cystic and glomerular inherited kidney diseases. Kidney Int. 2018; 94(2): 363-371. DOI:10.1016/j.kint.2018.02.027.

Vado Y, Errea Dorronsoro J, Llano Rivas I, Gorria N, Pereda A, Gener B, et al. Cri-du-chat syndrome mimics Silver-Russell syndrome depending on the size of the deletion: a case report. BMC Med Genomics. 2018; 11(1): 124-124. DOI:10.1186/s12920-018-0441-z.

Ochoa JP, Sabater Molina M, Garcia Pinilla JM, Mogensen J, Restrepo Cordoba A, Palomino Doza J, et al. Formin Homology 2 Domain Containing 3 (FHOD3) Is a Genetic Basis for Hypertrophic Cardiomyopathy. J Am Coll Cardiol. 2018; 72(20): 2457-2467. DOI:10.1016/j.jacc.2018.10.001.

Caamano V, Zaldumbide L, Saiz M, Andres L, Nogueira A, Diaz I, et al. Correlation between vascular density with metastasis and poor prognosis in clear cell renal cell carcinoma with venous tumour thrombus: review of 39 cases. Virchows Arch. 2018; 473(1): 193-193

Caamano V, Garcia E, Saiz M, Andres L, Malaxetxebarria S, Mosteiro L, et al. Solid pancreatic pseudopapillary tumour diagnosed by fnab-eusguided: a case report. Virchows Arch. 2018; 473(1): 218-218

Caamano V, Saiz M, Andres L, Mostciro L, Velasco V, Gonzalez M, et al. Leiomyosarcoma of the inferior vena cava: a case report. Virchows Arch. 2018; 473(1): 323-323

Caamano V, Saiz M, Andres L, Mosteiro L, Malaxetxebarria S, Velasco V, et al. A curious case of intravenous lobular capillary haemangioma (pyogenic granuloma) of the ovarian vein: a case report. Virchows Arch. 2018; 473(1): 322-322

Camin MS, Mosteiro L, Velasco V, Malaxetxebarria S, Caamano V, Gonzalez M, et al. Solitary fibrous tumour of the pleura: review of cases in a university hospital over the last twenty years. Virchows Arch. 2018; 473(1): 325-325

Andres L, Velasco V, Saiz M, Mosteiro L, Caamano V, Malaxetxebarria S, et al. Primary diffuse large B-cell lymphoma of the breast: report of 8 cases. Virchows Arch. 2018; 473: 200-200

Andres L, Velasco V, Saiz M, Mosteiro L, Caamano V, Malaxetxebarria S, et al. Mullerian adenosarcoma of the female genital tract: report of 8 cases and review of the literature. Virchows Arch. 2018; 473: 263-263

McNulty P, Pilcher R, Ramesh R, Necuiniate R, Hughes A, Farewell D, et al. Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study. J Huntingtons Dis. 2018; 7(3): 209-222. DOI:10.3233/JHD-170263.

Juan Mateu J, Alvelos MI, Turatsinze J, Villate O, Lizarraga Mollinedo E, Grieco FA, et al. SRp55 Regulates a Splicing Network That Controls Human Pancreatic beta-Cell Function and Survival. Diabetes. 2018; 67(3): 423-436. DOI:10.2337/db17-0736.

Munkley J, Maia TM, Ibarluzea N, Livermore KE, Vodak D, Ehrmann I, et al. Androgen-dependent alternative mRNA isoform expression in prostate cancer cells. F1000Res. 2018; 7: 1189-1189. DOI:10.12688/f1000research.15604.1.

Garcia Obregon S, Azkargorta M, Seijas I, Pilar Orive J, Borrego F, Elortza F, et al. Identification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patients. J Microbiol Immunol Infect. 2018; 51(4): 465-472. DOI:10.1016/j.jmii.2016.12.002.

Lopez Santillan M, Larrabeiti Etxebarria A, Arzuaga Mendez J, Lopez E, Garcia Orad A. Circulating miRNAs as biomarkers in diffuse large B-cell lymphoma: A systematic review. Oncotarget. 2018; 9(32): 22850-22861. DOI:10.18632/oncotarget.25230.

Aurtenetxe O, Zaldumbide L, Erramuzpe A, Lopez R, Lopez JI, Cortes JM, et al. DUSP5 expression associates with poor prognosis in human neuroblastoma. Exp Mol Pathol. 2018; 105(3): 272-278. DOI:10.1016/j.yexmp.2018.08.008.

Lucchini G, Marsh R, Gilmour K, Worth A, Nademi Z, Rao A, et al. Treatment dilemmas in asymptomatic children with primary hemophagocytic lymphohistiocytosis. Blood. 2018; 132(19): 2088-2096. DOI:10.1182/blood-2018-01-872485.

Alba Pavon P, Echebarria A, Garcia Obregon S, De Pedro JM, Adan R, Lopez Almaraz R, et al. Pediatric Patients Diagnosed with Bone Sarcomas: A Descriptive Study of 37 Cases. Pediatr Blood Cancer. 2018; 65(2): 308-308

Camino AG, Obregon SG, Lopez EL, Astigarraga I, Garcia Orad A. MicroRNAs as a New Tool for Diagnosis, Classification and Prognosis in Pediatric Acute Lymphoblastic Leukemia: A Systematic Review. Pediatr Blood Cancer. 2018; 65(2): 117-117

Martin Guerrero I, Bilbao Aldaiturriaga N, Gutierrez Camino A, Santos Zorrozua B, Dolzan V, Patino Garcia A, et al. Variants in the 14q32 miRNA cluster are associated with osteosarcoma risk in the Spanish population. Sci Rep. 2018; 8. DOI:10.1038/s41598-018-33712-4.

Salcines NB, Olabarri JMD, Pedroso R, Ariza MG, Barona AE, Almaraz RL, et al. LATE SPONTANEOUS RESOLUTION AFTER CONSERVATIVE ATTITUDE IN PEDIATRIC PATIENTS WITH CHRONIC PRIMARY IMMUNE THROMBOCYTOPENIA. Haematologica. 2018; 103(2): 272-272

Garcia Ariza M, Aurtenetxe O, Martin Guerrero I, Zaldumbide L, Astigarraga I, Llort A, et al. MOLECULAR STUDY IN PEDIATRIC MEDULLOBLASTOMA. VALIDATION OF GENETIC MARKERS IN A NATIONAL COHORT OF FORTY YEARS. Neuro-Oncology. 2018; 20(2): 124-125

Martin Guerrero I, Aurtenetxe O, Zaldumbide L, Astigarraga I, Hicks D, Schwalbe E, et al. METHYLATION PROFILE IN A RETROSPECTIVE SERIES OF SPANISH PEDIATRIC MEDULLOBLASTOMA. Neuro-Oncology. 2018; 20(2): 135-135

Perez Ruiz I, Meijide S, Hernandez ML, Navarro R, Ferrando M, Larreategui Z, et al. Antioxidant status of human follicular fluid: natural versus controlled ovarian hyper-stimulated cycles. Free Radic Biol Med. 2018; 120(1): 62-62. DOI:10.1016/j.freeradbiomed.2018.04.206.

Umerez M, Garcia Obregon S, Martin Guerrero I, Astigarraga I, Gutierrez Camino A, Garcia Orad A. Role of miRNAs in treatment response and toxicity of childhood acute lymphoblastic leukemia. Pharmacogenomics. 2018; 19(4): 361-373. DOI:10.2217/pgs-2017-0164.

Vitalle J, Terren I, Gamboa Urquijo L, Orrantia A, Tarancon Diez L, Genebat M, et al. Altered expression of CD300a inhibitory receptor on CD4+ T cells from human immunodeficiency virus-1-infected patients: Association with disease progression markers. Front Immunol. 2018; 9. DOI:10.3389/fimmu.2018.01709.

Zaldumbide L, Aurtenetxe O, Erramuzpe A, Saiz M, Lopez Almaraz R, Caamano V, et al. Neuroblastoma PTPome Analysis Unveils Association of PTPN1 And DUSP5 Expression With Poor Prognosis. Mod Pathol. 2018; 31(2): 720-720

Ehl S, Astigarraga I, Greenwood TV, Hines M, Horne A, Ishii E, et al. Recommendations for the Use of Etoposide-Based Therapy and Bone Marrow Transplantation for the Treatment of HLH: Consensus Statements by the HLH Steering Committee of the Histiocyte Society. J Allergy Clin Immunol-Pract. 2018; 6(5): 1508-1517. DOI:10.1016/j.jaip.2018.05.031.

Berastegui Zufiaurre N, Garcia Ariza M, Lopez EL, Santos Zorrozua B, Martin Guerrero I, Navajas A, et al. A Systematic Review of miRNAs as a New Tool for the Diagnosis of Pediatric Medulloblastoma. Pediatr Blood Cancer. 2018; 65(2): 434-434

Garcia Ariza M, Lopez EL, Martin Guerrero I, Navajas A, Garcia Orad A. Evaluation of the Role of microRNAs for Prognosis in Pediatric Medulloblastoma: A Systematic Review. Pediatr Blood Cancer. 2018; 65(2): 434-434

Pousa AE, Aguirre IA, Danobeitia NL, Almaraz RL, Olabarri JD, Pedroso RA, et al. Outpatient Parenteral Antimicrobial Therapy in Children and Young Adolescents Diagnosed with Cancer. Pediatr Blood Cancer. 2018; 65(2): 99-100

Bilbao N, De Pedro JM, Adan R, Larrinaga N, Ricondo A, Ojinaga I, et al. Hospital Admission Time for Newly Diagnosed Children and Adolescents with Acute Lymphoblastic Leukemia. Experience of One Spanish Unit. Pediatr Blood Cancer. 2018; 65(2): 95-95

Bilbao N, De Pedro JM, Echebarria Barona A, Amaia R, Itziar O, Alexandra E, et al. Fever at Diagnosis of Acute Lymphoblastic Leukemia: Is it Always Necessary to Indicate or Maintain Empirical Antibiotherapy?. Pediatr Blood Cancer. 2018; 65(2): 112-112

Martin Guerrero I, Ramis Zaldivar JE, Celis V, Balague O, Verdu J, Salmeron Villalobos J, et al. Global genetic profiling of a pediatric series of T-cell lymphoblastic lymphoma. Br J Haematol. 2018; 182: 64-64

de Rojas T, Bautista F, Flores M, Igual L, Rubio R, Bardon E, et al. Management and outcome of children and adolescents with non-medulloblastoma CNS embryonal tumors in Spain: room for improvement in standards of care. J Neuro-Oncol. 2018; 137(1): 205-213. DOI:10.1007/s11060-017-2713-4.

Doz F, Clifford S, Pietsch T, Avula S, Mynarek M, Riechers R, et al. FEASIBILITY OF SCREENING AND REASONS FOR SCREENING FAILURES IN THE SIOPE PNET 5 MB TRIAL. Neuro-Oncology. 2018; 20(2): 122-123

Astigarraga I, Gonzalez Granado LI, Allende LM, Alsina L. Haemophagocytic syndromes: The importance of early diagnosis and treatment. An Pediatr. 2018; 89(2). DOI:10.1016/j.anpedi.2018.05.003.

Bueren JA, Navarro S, Wang W, Sanchez Dominguez R, Merino E, Segovia JC, et al. Advances in the Gene Therapy of Patients with Fanconi Anemia. Blood. 2018; 132. DOI:10.1182/blood-20-99-111160.

Ramis Zaldivar JE, Gonzalez Farre B, Olga B, Celis V, Nadeu F, Andres M, et al. Large B-Cell Lymphomas in Pediatric and Young Adults Display Clinically Relevant Molecular Features Distinguishable from Adult Counterparts. Blood. 2018; 132(1). DOI:10.1182/blood-2018-99-114493.

Zaldumbide L, Aurtenetxe O, Erramuzpe A, Saiz M, Lopez Almaraz R, Caamano V, et al. Neuroblastoma PTPome Analysis Unveils Association of PTPN1 And DUSP5 Expression With Poor Prognosis. Lab Invest. 2018; 98(1): 720-720

Sanmartín E, Ortiz Martínez F, Pomares Navarro E, García Martínez A, Rodrigo Baños M, García Escolano M, et al. CD44 induces FOXP3 expression and is related with favorable outcome in breast carcinoma. Virchows Arch. 2017; 470(1): 81-90. DOI:10.1007/s00428-016-2045-3.

Luna S, Mingo J, Amo L, Rodriguez Escudero I, Erramuzpe A, Molina M, et al. Readthrough response of pathogenic premature termination codons at PTEN gene: implications in precision therapy for PHTS patients. Ann Oncol. 2017; 28(7)

Garcia Ariza M, Lopez Almaraz R, Echebarria Barona A, Adan Pedroso R, Ojinaga Nino I, Ricondo De Diego A, et al. Experience of the Management of Central Nervous System Tumors in Children Younger than 5 Years-Old in the Last 15 Years. Pediatr Blood Cancer. 2017; 64(3): 304-304

Axpe IR, Martin EB, Ribes AG, Bermejo Ramirez R, Andujar DA. Sensory-motor neuropathy in a case with SPG35: Expanding the phenotype. J Neurol Sci. 2017; 380: 98-100. DOI:10.1016/j.jns.2017.05.054.

Gonzalez Quereda L, Rodriguez M, Nascimento A, Ortez C, Jou C, Milisenda J, et al. Two different NGS approaches to address molecular diagnosis of congenital neuromuscular diseases. Neuromusc Disord. 2017; 27(2): 197-197. DOI:10.1016/j.nmd.2017.06.375.

Zaldumbide L, Fernandez Lomana E, Atienza M, Nogueira A, Marcos A, de Casasola GG, et al. Infantile desmoplastic ganglioglioma, a case report. Virchows Arch. 2017; 471(1): 221-221

Villaverde VC, Vadillo MG, Gonzalez LM, Camin MS, Benito VV, Alvarez LA, et al. Pancreatic mx diagnosis of Clear Renal Cell Carcinoma (CRCC) by fnab-eus-guided: Review of 2 cases. Virchows Arch. 2017; 471(1): 310-310

Martinez Castrillo JC, Pena Segura JL, Sanz Cartagena P, Alonso Curco X, Arbelo Gonzalez JM, Arriola Pereda G, et al. Myths and evidence on the use of botulinum toxin: spasticity in adults and in children with cerebral palsy. Rev Neurologia. 2017; 64(10): 459-470. DOI:10.33588/rn.6410.2016488.

Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindstrom S, et al. Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Nat Genet. 2017; 49(12): 1767-1778. DOI:10.1038/ng.3785.

Villaverde VC, Vadillo MG, Gonzalez LM, Benito VV, Camin MS, Alvarez LA, et al. Chondromyxoid fibroma: Report of three cases. Virchows Arch. 2017; 471(1): 260-261

Natera de Benito D, Topf A, Vilchez JJ, Gonzalez Quereda L, Dominguez Carral J, Diaz Manera J, et al. Molecular characterization of congenital myasthenic syndromes in Spain. Neuromusc Disord. 2017; 27(12): 1087-1098. DOI:10.1016/j.nmd.2017.08.003.

Balhuizen A, Massa S, Mathijs I, Turatsinze JV, De Vos J, Demine S, et al. A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells. Sci Rep. 2017; 7(1): 15130-15130. DOI:10.1038/s41598-017-15417-2.

Zenarruzabeitia O, Vitallé J, Astigarraga I, Borrego F. Natural Killer Cells to the Attack: Combination Therapy against Neuroblastoma. Clin Cancer Res. 2017; 23(3): 615-617. DOI:10.1158/1078-0432.CCR-16-2478.

Bautista F, Gallego S, Cañete A, Mora J, Díaz de Heredia C, Cruz O, et al. Early clinical trials in paediatric oncology in Spain: a nationwide perspective. An Pediatr. 2017; 87(3): 155-163. DOI:10.1016/j.anpedi.2016.07.007.

Lopez Santillan M, Iparraguirre L, Martin Guerrero I, Gutierrez Camino A, Garcia Orad A. Review of pharmacogenetics studies of L-asparaginase hypersensitivity in acute lymphoblastic leukemia points to variants in the GRIA1 gene. Drug Metab Personalized Ther. 2017; 32(1): 1-9. DOI:10.1515/dmpt-2016-0033.

Bilbao Aldaiturriaga N, PatiNo Garcia A, Martin Guerrero I, Garcia Orad A. Cytotoxic T lymphocyte-associated antigen 4 rs231775 polymorphism and osteosarcoma. Neoplasma. 2017; 64(2): 299-299. DOI:10.4149/neo_2017_218.

Rio P, Navarro S, Guenechea G, Galy A, Sanchez R, Lamana ML, et al. First Evidence of Engraftment and Repopulation Advantage of Gene-Corrected Hematopoietic Precursors in Non-Conditioned Fanconi Anemia Patients. Mol Ther. 2017; 25(5): 348-349

Sevilla J, Rio P, Navarro S, Galvez E, Sebastian E, Guenechea G, et al. FIRST EVIDENCE DEMONSTRATING ENGRAFTMENT AND REPOPULATION ADVANTAGE OF GENE-CORRECTED HEMATOPOIETIC REPOPULATING CELLS IN NON-CONDITIONED FANCONI ANEMIA PATIENTS. Haematologica. 2017; 102(2): 21-22

Astigarraga I, Garcia Obregon S, Gil Herrera J, Echebarria A, Adan R, Garcia Ariza M, et al. Early Onset of HLH and Inherited UNC13D and JAK3 Mutations in a Patient. A Difficult Diagnostic and Therapeutic Challenge. Pediatr Blood Cancer. 2017; 64(2): 1-2

Gutierrez Camino A, Martin Guerrero I, Garcia Orad A. Genetic susceptibility in childhood acute lymphoblastic leukemia. Med Oncol. 2017; 34(10): 179-179. DOI:10.1007/s12032-017-1038-7.

Garcia Ariza M, Echebarria Barona A, Lopez Almaraz R, Adan Pedroso R, Bilbao Salcines N, Ricondo De Diego A, et al. Tumors of the Central Nervous System in the First Year of Life. One Single Institution Experience. Pediatr Blood Cancer. 2017; 64(3): 462-462

Garcia Ariza M, Lopez Almaraz R, Echebarria Barona A, Adan Pedroso R, Ojinaga Nino I, Ricondo De Diego A, et al. Experience of the Management of Central Nervous System Tumors in Children Younger than 5 Years-Old in the Last 15 Years. Pediatr Blood Cancer. 2017; 64(3): 304-304

Gutierrez camino A, Martin guerrero I, Garcia De Andoin N, Navajas A, Sastre A, Carbone baneres A, et al. MIR-3117 and MIR-3689D2 in MAPK Signaling Pathway: Implication in Childhood Acute Lymphoblastic Leukemia Susceptibility. Pediatr Blood Cancer. 2017; 64(3): 175-176

Umerez M, Gutierrez Camino A, Garcia Ariza M, Sastre A, Garcia de Andoin N, Echebarria Barona A, et al. SNPS in Micrornas Associated with Vincristine Induced Neurotoxicity in Spanish Children with Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2017; 64(3): 402-402

Lopez Almaraz R, Echebarria Barona A, Gonzalez Camacho U, De Pedro Olabarri JM, Garcia Ariza M, Adan Pedroso R, et al. PET/TC Utility in the Assessment of the Response to Treatment in Pediatric Lymphomas. Pediatr Blood Cancer. 2017; 64(3): 443-444

Lopez Almaraz R, Garcia Ariza M, De Pedro Olabarri JM, Gonzalez Camacho U, Echebarria Barona A, Adan Pedroso R, et al. Value of PET/CT in Treatment Response to Chemotherapy in Musculoskeletal Tumors. Pediatr Blood Cancer. 2017; 64(3): 406-406

Tagarelli A, Orbach D, Lopez Almaraz R, Pourtsidis A, Bien E, Osterlundh G, et al. Are Very Rare Tumors Correctly Recognized? A European Survey on Pleuropulmonary Blastoma. Pediatr Blood Cancer. 2017; 64(3): 131-131

Gutierrez Camino A, Oosterom N, den Hoed M, Lopez E, Martin Guerrero I, Pluijm SMF, et al. The miR-1206 microRNA variant is associated with methotrexate-induced oral mucositis in pediatric acute lymphoblastic leukemia. Pharmacogenet Genomics. 2017; 27(8): 303-306. DOI:10.1097/FPC.0000000000000291.

Umerez M, Gutierrez Camino A, Munoz Maldonado C, Martin Guerrero I, Garcia Orad A. MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy. Pharmacogn Pers Med. 2017; 10: 69-78. DOI:10.2147/PGPM.S107047.

Gutierrez Camino A, Martin Guerrero I, Garcia Orad A. PNPLA3 rs738409 and Hepatotoxicity in Children With B-cell Acute Lymphoblastic Leukemia: A Validation Study in a Spanish Cohort. Clin Pharmacol Ther. 2017; 102(6): 906-906. DOI:10.1002/cpt.756.

Garrido Colino C, Lassaletta A, Vazquez MA, Echevarria A, Gutierrez I, Andion M, et al. Current situation on fertility preservation in cancer patients in Spain: Level of knowledge, information, and professional involvement. An Pediatr. 2017; 87(1): 3-8. DOI:10.1016/j.anpedi.2016.04.019.

Gonzalez Farre B, Balague O, Martin Guerrero I, Garrido M, Gaafar A, Sunol M, et al. Large B-cell Lymphomas in Pediatric and Young Adult Population Are Genetically Heterogeneous. Mod Pathol. 2017; 30(2): 351-351

Gonzalez Farre B, Balague O, Martin Guerrero I, Garrido M, Gaafar A, Sunol M, et al. Large B-cell Lymphomas in Pediatric and Young Adult Population Are Genetically Heterogeneous. Lab Invest. 2017; 97(1): 351-351

Bergsten E, Horne A, Arico M, Astigarraga I, Egeler RM, Filipovich AH, et al. Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study. Blood. 2017; 130(25): 2728-2738. DOI:10.1182/blood-2017-06-788349.

Astigarraga I, Garcia Obregon S, Capape S, Ortiz Calahorro J, Fernandez Bernal M, Pena A, et al. Prophylaxis and therapy of tumor lysis syndrome in 115 pediatric patients diagnosed with hematological neoplasms. Eur J Cancer. 2017; 72(1): 147-147. DOI:10.1016/S0959-8049(17)30557-9.

Astigarraga I, Menchaca M, Lopez DelaSerna MJ, Garcia Obregon S, Adan R, Echebarria A, et al. Management and early complications of totally implantable venous access port systems in 81 children diagnosed with cancer. Eur J Cancer. 2017; 72(1): 146-146. DOI:10.1016/S0959-8049(17)30556-7.

Guterrez Camino A, Martin Guerrero I, de Andoin NG, Navajas A, Sastre A, Baneres AC, et al. Involvement of SNPS in mir3117 and mir3689 in pediatric acute lymphoblastic leukemia susceptibility. Eur J Cancer. 2017; 72(1): 144-144. DOI:10.1016/S0959-8049(17)30548-8.

Gutierrez Camino A, Martin Guerrero I, de Andoin NG, Navajas A, Sastre A, Baneres AC, et al. Involvement of SNPS in CDKN2A/B locus in childhood acute lymphoblastic leukemia susceptibility in the Spanish population. Eur J Cancer. 2017; 72(1): 144-144. DOI:10.1016/S0959-8049(17)30547-6.

Umerez M, Gutierrez Camino A, Martin Guerrero I, De Andoin NG, Sastre A, Navajas A, et al. SNPS in microRNAs associated with methotrexate plasma levels in Spanish children with acute lymphoblastic leukemia. Eur J Cancer. 2017; 72(1): 143-143. DOI:10.1016/S0959-8049(17)30546-4.

Minoia F, Bovis F, Davi S, Insalaco A, Lehmberg K, Shenoi S, et al. Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome. J Pediatr. 2017; 189: 72-72. DOI:10.1016/j.jpeds.2017.06.005.

Del Orbe Barreto R, Arrizabalaga B, De la Hoz Rastrollo AB, Garcia Orad A, Gonzalez Vallejo I, Bento C, et al. Hereditary xerocytosis, a misleading anemia. Ann Hematol. 2016; 95(9): 1545-1546. DOI:10.1007/s00277-016-2716-9.

Schonewolf Greulich B, Tejada M-, Stephens K, Hadzsiev K, Gauthier J, Brondum Nielsen K, et al. The MECP2 variant c.925C > T (p.Arg309Trp) causes intellectual disability in both males and females without classic features of Rett syndrome. Clin Genet. 2016; 89(6): 733-738. DOI:10.1111/cge.12769.

Del Orbe Barreto R, Arrizabalaga B, de la Hoz AB, Araguees P, Garcia Ruiz JC, Arrieta A, et al. Severe neonatal jaundice due to a de novo glucose-6-phosphate dehydrogenase deficient mutation. Int J Lab Hematol. 2016; 38(2): 27-29. DOI:10.1111/ijlh.12455.

Calmels N, Greff G, Obringer C, Kempf N, Gasnier C, Tarabeux J, et al. Uncommon nucleotide excision repair phenotypes revealed by targeted high-throughput sequencing. Orphanet J Rare Dis. 2016; 11: 26-26. DOI:10.1186/s13023-016-0408-0.

Hirata Y, Brems H, Suzuki M, Kanamori M, Okada M, Morita R, et al. Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1. J Biol Chem. 2016; 291(7): 3124-3134. DOI:10.1074/jbc.M115.703710.

Rubio I, Ibanez Feijoo E, Andres L, Aguirre E, Balmana J, Blay P, et al. Analysis of Lynch Syndrome Mismatch Repair Genes on Women with Endometrial Cancer. Oncology. 2016; 91(3): 171-176. DOI:10.1159/000447972.

Natera de Benito D, Bestue M, Vilchez JJ, Evangelista T, Toepf A, Garcia Ribes A, et al. Long-term follow-up in patients with congenital myasthenic syndrome due to RAPSN mutations. Neuromusc Disord. 2016; 26(2): 153-159. DOI:10.1016/j.nmd.2015.10.013.

Fergelot P, Van Belzen M, Van Gils J, Afenjar A, Armour CM, Arveiler B, et al. Phenotype and Genotype in 52 Patients with Rubinstein-Taybi Syndrome Caused by EP300 Mutations. Am J Med Genet A. 2016; 170(12): 3069-3082. DOI:10.1002/ajmg.a.37940.

Del Orbe Barreto R, Arrizabalaga B, De la Hoz AB, García Orad Á, Tejada MI, Garcia Ruiz JC, et al. Detection of new pathogenic mutations in patients with congenital haemolytic anaemia using next-generation sequencing. Int J Lab Hematol. 2016; 38(6): 629-638. DOI:10.1111/ijlh.12551.

Merino S, Ibarluzea N, Maortua H, Prieto B, Rouco I, Lopez Ariztegui M, et al. Associated Clinical Disorders Diagnosed by Medical Specialists in 188 FMR1 Premutation Carriers Found in the Last 25 Years in the Spanish Basque Country: A Retrospective Study. Genes. 2016; 7(10). DOI:10.3390/genes7100090.

Barreto Rafael DO, Beatriz A, Ana Belen DH, Martitegui Xabier M, Africa G, Javier M, et al. IDENTIFICATION OF TWO NEW MUTATIONS IN THE GENE OF THE ANCHIRINE CAUSES OF HEREDITARY SPHEROCYTOSIS. Haematologica. 2016; 101(4): 260-260

Andres L, Caamano V, Lomana EMF, Atienza M, Nogueira A. Atypical endometriosis: A clinicopathological study of 6 cases. Virchows Arch. 2016; 469(1): 277-277

Olaechea PM, Álvarez Lerma F, Palomar M, Gimeno R, Gracia MP, Mas N, et al. Characteristics and outcomes of patients admitted to Spanish ICU: A prospective observational study from the ENVIN-HELICS registry (2006-2011). Med Intensiv. 2016; 40(4): 216-229. DOI:10.1016/j.medin.2015.07.003.

Zenarruzabeitia O, Vitalle J, Garcia Obregon S, Astigarraga I, Eguizabal C, Santos S, et al. The expression and function of human CD300 receptors on blood circulating mononuclear cells are distinct in neonates and adults. Sci Rep. 2016; 6: 32693-32693. DOI:10.1038/srep32693.

Del Orbe Barreto R, Arrizabalaga B, De la Hoz Rastrollo AB, Garcia Orad A, Gonzalez Vallejo I, Bento C, et al. Hereditary xerocytosis, a misleading anemia. Ann Hematol. 2016; 95(9): 1545-1546. DOI:10.1007/s00277-016-2716-9.

Bautista F, Gallego S, Canete A, Mora J, Diaz de Heredia C, Cruz O, et al. Landscape of early clinical trials for childhood and adolescence cancer in Spain. Clin Transl Oncol. 2016; 18(7): 708-713. DOI:10.1007/s12094-015-1421-9.

Olaia A, laura Z, Idoia M, Ayman G, Miguel G, Aurora N. SPANISH EXPERIENCE IN PEDIATRIC MEDULLOBLASTOMA. Neuro-Oncology. 2016; 18(3): 114-115

Rivero G, Martin Guerrero I, de Prado E, Gabilondo AM, Callado LF, Garcia Sevilla JA, et al. Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence. World J Biol Psychiatry. 2016; 17(4): 308-315. DOI:10.3109/15622975.2016.1142608.

Del Orbe Barreto R, Arrizabalaga B, de la Hoz AB, Araguees P, Garcia Ruiz JC, Arrieta A, et al. Severe neonatal jaundice due to a de novo glucose-6-phosphate dehydrogenase deficient mutation. Int J Lab Hematol. 2016; 38(2): 27-29. DOI:10.1111/ijlh.12455.

Garcia Ariza M, Echevarria Ecenarro J, Echebarria A, Adan R, Lopez Almaraz R, Astigarraga I, et al. VISUAL ACUITY SURVEILLANCE IN PAEDIATRIC PATIENTS WITH OPTIC PATHWAY GLIOMA. EXPERIENCE IN A SPANISH SINGLE INSTITUTION. Neuro-Oncology. 2016; 18(3): 87-87

Garcia Ariza M, Portillo Najera N, Gonzalez Camacho U, Rubio Rojas R, Vela De Sojo A, Rica I, et al. 10 YEARS REVIEW OF ENDOCRINOLOGICAL LATE EFFECTS IN SPANISH PATIENTS WITH PRIMARY BRAIN TUMORS IN A TERTIARY HOSPITAL. Neuro-Oncology. 2016; 18(3): 151-151

Iparraguirre L, Gutierrez Camino A, Umerez M, Martin Guerrero I, Astigarraga I, Navajas A, et al. MiR-pharmacogenetics of methotrexate in childhood B-cell acute lymphoblastic leukemia. Pharmacogenet Genomics. 2016; 26(11): 517-525. DOI:10.1097/FPC.0000000000000245.

Astigarraga I, Garcia Obregon S, Ceberio L, Adan R, Echebarria A, Garcia Ariza M, et al. A Collaborative Study in Children and Adults Diagnosed with Langerhans Cell Histiocytosis. Our Experience in 42 Cases. Pediatr Blood Cancer. 2016; 63(2): 10-11

Chellapandian D, Zhang R, Jeng M, van den Bos C, Lopez VS, Lehmberg K, et al. Hemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Multicenter Retrospective Descriptional Study. Pediatr Blood Cancer. 2016; 63(2): 38-39

Garcia Obregon S, Seijas I, Pilar Orive J, Ruano C, Pena A, Zenarruzabeitia O, et al. High Levels of sCD25 and sCD163 in Patients Diagnosed with Sepsis. Could They be Useful for Sepsis Diagnosis and Differential Diagnosis with Hemophagocytic Lymphohistiocytosis (HLH)?. Pediatr Blood Cancer. 2016; 63(2): 42-42

Bilbao Aldaiturriaga N, Askaiturrieta Z, Granado Tajada I, Goricar K, Dolzan V, Garcia Miguel P, et al. A systematic review and meta-analysis of MDM2 polymorphisms in osteosarcoma susceptibility. Pediatr Res. 2016; 80(4): 472-479. DOI:10.1038/pr.2016.120.

Sabel M, Fleischhack G, Tippelt S, Gustafsson G, Doz F, Kortmann R, et al. Relapse patterns and outcome after relapse in standard risk medulloblastoma: a report from the HIT-SIOP-PNET4 study. J Neuro-Oncol. 2016; 129(3): 515-524. DOI:10.1007/s11060-016-2202-1.

Iskrov G, Astigarraga I, Stefanov R, Lopez Bastida J, Linertova R, Oliva Moreno J, et al. Social/economic costs and health-related quality of life in patients with histiocytosis in Europe. Eur J Health Econ. 2016; 17(1): 67-78. DOI:10.1007/s10198-016-0790-5.

Selva Folch B, Lopez Almaraz R, Sanchez Gonzale R, Martinez de las Heras B. Diffuse cutaneous mastocytosis. Presentation of 3 cases and therapeutic management review. An Pediatr. 2016; 84(5): 286-288. DOI:10.1016/j.anpedi.2015.07.003.

Berbegall AP, Lopez Almaraz R, Navarro S, Noguera R. Genetic features of neuroblastic tumors associated with opsoclonus-myoclonus syndrome opens up the possibility for detection in peripheral blood. Expert Rev Neurother. 2016; 16(5): 465-467. DOI:10.1586/14737175.2016.1163221.

Rio P, Navarro S, Guenechea G, Galy A, Sanchez R, Lamana ML, et al. Lentiviral-Mediated Gene Correction of Mobilized Peripheral Blood Progenitors and Repopulating Cells from FA-A Patients. Mol Ther. 2016; 24(1): 297-298. DOI:10.1016/S1525-0016(16)33561-4.

Bravo J, Lopez Almaraz R, Mateos M, Diaz L, Hernandez Exposito S. Neuropsychological profile in opsoclonus-myoclonus-ataxia syndrome presenting as neuroblastic tumours. Rev Neurologia. 2016; 62(6): 249-257. DOI:10.33588/rn.6206.2015428.

de Kock L, Bah I, Brunet J, Druker H, Astigarraga I, Bosch Barrera J, et al. Somatic DICER1 mutations in adult-onset pulmonary blastoma. Eur Resp J. 2016; 47(6): 1879-1882. DOI:10.1183/13993003.00172-2016.

Del Orbe Barreto R, Arrizabalaga B, De la Hoz AB, García Orad Á, Tejada MI, Garcia Ruiz JC, et al. Detection of new pathogenic mutations in patients with congenital haemolytic anaemia using next-generation sequencing. Int J Lab Hematol. 2016; 38(6): 629-638. DOI:10.1111/ijlh.12551.

Almaraz RL, Astigarraga I, Echebarria A, Olabarri JMP, Camacho UG, Pedroso RMA, et al. Brain Metastases in Paediatric Patients with Extracranial Solid Primary Cancer: 30-Years Experience. Pediatr Blood Cancer. 2016; 63(3): 136-136

Astigarraga I, Calvo Escribano C, Ramirez Villar GL, Marquez Vega C. Empowerment of patients and physicians' role in the long-term follow-up survivors of childhood cancer. Med Clin. 2016; 147(11): 511-515. DOI:10.1016/j.medcli.2016.06.017.

Echebarria A, Garcia N, De Pedro J, Gonzalez U, Garcia Obregon S, Capape S, et al. Metabolic Complications During Induction Therapy in Children with Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2016; 63(3): 104-105

Gutierrez Camino A, Martin Guerrero I, Garcia de Andoin N, Navajas A, Sastre A, Carbone Baneres A, et al. CDKN2A/CDKN2B as a Hotspot for Acute Lymphoblastic Leukemia Susceptibility in the Spanish Population. Pediatr Blood Cancer. 2016; 63(3): 65-66

Gutierrez Camino A, Fernandez Varona S, de Andoin NG, Navajas A, Sastre A, Baneres AC, et al. MIR3166, MIR3144 and MIR4745 are Associated with Acute Lymphoblastic Leukemia Susceptibility in the Spanish Population. Pediatr Blood Cancer. 2016; 63(3): 106-106

Iparraguirre L, Gutierrez Camino A, Umerez M, Martin Guerrero I, de Andoin NG, Sastre A, et al. Variants in MIR-5189, MIR-595 and MIR-6083 Associated with Methotrexate Plasma Levels in Snpanish Patients with Paediatric Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2016; 63(3): 106-106

Martin Guerrero I, Bilbao Aldaiturriaga N, Gutierrez Camino A, Uriz J, Garcia AP, Garcia Orad A. Four Variants in 14q32 Mirna Cluster are Associated with the Risk of Osteosarcoma in the Spanish Population. Pediatr Blood Cancer. 2016; 63(3): 124-124

Proserpio T, Veneroni L, Silva M, Lassaletta A, Lorenzo R, Magni C, et al. Spiritual support for adolescent cancer patients: a survey of pediatric oncology centers in Italy and Spain. Tumori J. 2016; 102(4): 376-380. DOI:10.5301/tj.5000494.

Grau G, Portillo N, Lopez Almaraz R, Echebarria A, Adan R, Rodriguez A, et al. Severe Hypertriglyceridemia in Pediatric Oncology Patient. Horm Res Paediatr. 2016; 86(1): 301-302

Portillo N, Gonzalez U, Rubio R, Garcia Ariza M, Grau G, Vela A, et al. 10 Years Review of Endocrine Diseases in Spanish Patients Diagnosed with Primary Brain Tumors in a Tertiary Hospital. Horm Res Paediatr. 2016; 86(1): 433-433

Bravo J, López Almaraz R, Mateos M, Díaz L, Hernández Expósito S. Perfil neuropsicologico en el sindrome opsoclono-mioclono-ataxia como forma de presentacion de tumores neuroblasticos. Rev Neurologia. 2016; 62(6): 249-257. DOI:10.33588/rn.6206.2015428.

Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016; 127(22): 2672-2681. DOI:10.1182/blood-2016-01-690636.

de Rojas T, Jose Bautista F, Flores M, Fioravantti V, Igual L, Rubio R, et al. DIAGNOSIS, MANAGEMENT AND OUTCOME OF CHILDREN WITH CENTRAL NERVOUS SYSTEM (CNS) PRIMITIVE NEUROECTODERMAL TUMORS (PNET) IN SPAIN: A STUDY FROM THE SPANISH NATIONAL PEDIATRIC ONCOLOGY & HEMATOLOGY SOCIETY (SEHOP). Neuro-Oncology. 2016; 18(3): 9-10

Barreto Rafael DO, Beatriz A, Ana Belen DH, Martitegui Xabier M, Africa G, Javier M, et al. IDENTIFICATION OF TWO NEW MUTATIONS IN THE GENE OF THE ANCHIRINE CAUSES OF HEREDITARY SPHEROCYTOSIS. Haematologica. 2016; 101(4): 260-260

Gonzalez Escudero R, Gomez Dermit V, Lopez Almaraz R. Unilateral exophthalmos of short evolution. A form of a neuroblastoma debut. Bol Pediatr. 2016; 56(237): 186-190

Luisa Lozano M, Cook A, Maria Bastida J, Paul DS, Iruin G, Rosa Cid A, et al. Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction. Blood. 2016; 128(9): 1282-1289. DOI:10.1182/blood-2015-11-683102.

Moreno L, García Ariza MA, Cruz O, Calvo C, Fuster JL, Salinas JA, et al. Citarabina liposomal para el tratamiento de la diseminación leptomeníngea en tumores del sistema nervioso central en niños y adolescentes. An Pediatr. 2016; 85(5). DOI:10.1016/j.anpedi.2016.02.007.

Oosterom N, Guttierez Camino A, den Hoed MA, Lopez E, Martin Guerrero I, Pluijm SM, et al. MIR-1206 Micro-RNA Variant is Associated with Methotrexate-Induced Mucositis in Paediatric Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2016; 63(3): 115-115

Peterlongo P, Chang Claude J, Moysich KB, Rudolph A, Schmutzler RK, Simard J, et al. Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. Cancer Epidemiol Biomarkers Prev. 2015; 24(1): 308-316. DOI:10.1158/1055-9965.EPI-14-0532.

Crow YJ, Chase DS, Schmidt JL, Szynkiewicz M, Forte GMA, Gornall HL, et al. Characterization of Human Disease Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1. Am J Med Genet A. 2015; 167(2): 296-312. DOI:10.1002/ajmg.a.36887.

Sanmartin E, Ortiz Martinez F, Pomares Navarro E, Andres L, Ponce J, Ballester H, et al. CD44 Is Associated With FOXP3 Expression and Favorable Outcome in Patients with Breast Carcinoma. Lab Invest. 2015; 95(1): 64-64

Pomares Navarro E, Perez Balaguer A, Sanmartin E, Ortiz Martinez F, Andres L, Ponce J, et al. Hedgehog Signaling in Immunophenotypes of Breast Carcinoma: A Gene Expression and Clinicalpathological Study. Lab Invest. 2015; 95(1): 61-61

Codina Sola M, Rodriguez Santiago B, Homs A, Santoyo J, Rigau M, Aznar Lain G, et al. Integrated analysis of whole-exome sequencing and transcriptome profiling in males with autism spectrum disorders. Mol Autism. 2015; 6(1). DOI:10.1186/s13229-015-0017-0.

Bauer M, Koelsch U, Krueger R, Unterwalder N, Hameister K, Kaiser FM, et al. Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome. J Clin Immunol. 2015; 35(2): 168-181. DOI:10.1007/s10875-015-0129-5.

Ortiz Martinez F, Sanmartin E, Pomares Navarro E, Perez Balaguer A, Andres L, Sanchez Paya J, et al. Osteopontin Regulates VEGFA and ICAM-1 mRNA Expression in Breast Carcinoma. Am J Clin Pathol. 2015; 143(6): 812-822. DOI:10.1309/AJCP6F2VNDAMSULA.

Pomares Navarro E, Perez Balaguer A, Sanmartin E, Ortiz Martinez F, Andres L, Ponce J, et al. Hedgehog Signaling in Immunophenotypes of Breast Carcinoma: A Gene Expression and Clinicalpathological Study. Mod Pathol. 2015; 28(2): 61-61

Rueda J, Guillen V, Ballesteros J, Tejada M, Sola I. L-acetylcarnitine for treating fragile X syndrome. Cochrane Database Syst Rev. 2015. DOI:10.1002/14651858.CD010012.pub2.

Sanmartin E, Ortiz Martinez F, Pomares Navarro E, Andres L, Ponce J, Ballester H, et al. CD44 Is Associated With FOXP3 Expression and Favorable Outcome in Patients with Breast Carcinoma. Mod Pathol. 2015; 28(2): 64-64

de la Hoz AB, Maortua H, García Rives A, Martínez González MJ, Ezquerra M, Tejada MI. 3p14 De Novo Interstitial Microdeletion in a Patient with Intellectual Disability and Autistic Features with Language Impairment: A Comparison with Similar Cases. Case Rep Genet. 2015; 2015: 876348-876348. DOI:10.1155/2015/876348.

Ancin Arteaga I, Landeta E, Amarika I, Maruri N, Olivares N, Rinon M, et al. BABIES WITH ACUTE LEUKEMIA OF AMBIGIOUS LINEAGE AND T (4;11) (Q21;Q23)/ MLL-AF4 REARRANGEMENT. Haematologica. 2015; 100(4): 237-238

Aristizabal A, Merino S, Catediano E, Sasieta M, Araguees P, Navajas A. Clinical consequences of alpha-thalassemia in the basque country, Spain. Impact of neonatal screening. An Pediatr. 2015; 83(2): 85-88. DOI:10.1016/j.anpedi.2014.10.014.

Luisa Martinez Fernandez M, Fernandez Toral J, Llano Rivas I, Bermejo Sanchez E, MacDonald A, Luisa Martinez Frias M. Delineation of the Clinically Recognizable 17q22 Contiguous Gene Deletion Syndrome in a Patient Carrying the Smallest Microdeletion Known to Date. Am J Med Genet A. 2015; 167(9): 2034-2041. DOI:10.1002/ajmg.a.37117.

Rojnueangnit K, Xie J, Gomes A, Sharp A, Callens T, Chen Y, et al. High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype-Phenotype Correlation. Hum Mutat. 2015; 36(11): 1052-1063. DOI:10.1002/humu.22832.

Grozeva D, Carss K, Spasic Boskovic O, Tejada M, Gecz J, Shaw M, et al. Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability. Hum Mutat. 2015; 36(12): 1197-1204. DOI:10.1002/humu.22901.

Del Orbe Barreto R, Arrizabalaga B, De la Hoz AB, Tejada I, Araguees P, Silva C, et al. THE "NEXT GENERATION SEQUENCING" UTILITY IN THE OPTIMIZATION OF THE DIAGNOSIS OF THE CONGENITAL HEMOLITICAS ANEMIA. Haematologica. 2015; 100(4): 1-2

Rebbeck TR, Mitra N, Wan F, Sinilnikova OM, Healey S, McGuffog L, et al. Association of Type and Location of BRCA1 and BRCA2 Mutations With Risk of Breast and Ovarian Cancer. JAMA-J Am Med Assoc. 2015; 313(13): 1347-1361. DOI:10.1001/jama.2014.5985.

Kuchenbaecker KB, Ramus S, Tyrer J, Lee A, Shen HC, Beesley J, et al. Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet. 2015; 47(2): 164-171. DOI:10.1038/ng.3185.

Astigarraga I. Avances y retos en la lucha contra el cáncer infantil. An Pediatr. 2015; 82(2): 57-58. DOI:10.1016/j.anpedi.2014.11.001.

Martínez Uña M, Varela Rey M, Mestre D, Fernández Ares L, Fresnedo O, Fernandez Ramos D, et al. S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease. J Hepatol. 2015; 62(3): 673-681. DOI:10.1016/j.jhep.2014.10.019.

Pombar Gomez M, Lopez E, Martin Guerrero I, Garcia Orad Carles A, de Pancorbo MM. Potential relationship between single nucleotide polymorphisms used in forensic genetics and diseases or other traits in European population. Int J Legal Med. 2015; 129(3): 435-443. DOI:10.1007/s00414-015-1165-7.

Bilbao Aldaiturriaga N, Gutierrez Camino A, Martin Guerrero I, Pombar Gomez M, Zalacain Diez M, Patino Garcia A, et al. Polymorphisms in miRNA Processing Genes and Their Role in Osteosarcoma Risk. Pediatr Blood Cancer. 2015; 62(5): 766-769. DOI:10.1002/pbc.25416.

Astigarraga I, Garcia Obregon S, Agirrebengoa K, Balerdi A, Carlos Garcia Ruiz J, Diaz B, et al. HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS COMPLICATING ADULT PATIENTS WITH HIV INFECTION. Pediatr Blood Cancer. 2015; 62(1): 2-2

Martin Guerrero I, Gutierrez Camino A, Lopez E, Bilbao Aldaiturriaga N, Pombar Gomez M, Ardanaz M, et al. Genetic Variants in MiRNA Processing Genes and Pre-MiRNAs Are Associated with the Risk of Chronic Lymphocytic Leukemia. PLoS One. 2015; 10(3). DOI:10.1371/journal.pone.0118905.

Astigarraga I. Advances and challenges in the fight against childhood cancer. An Pediatr. 2015; 82(2): 57-58. DOI:10.1016/j.anpedi.2014.11.001.

Abla O, Weitzman S, Chellapandian D, Abuhadra N, Carret A, Astigarraga I, et al. MANAGEMENT AND OUTCOME OF PATIENTS WITH LANGERHANS CELL HISTIOCYTOSIS AND SINGLE-BONE CNS-RISK LESIONS: A MULTI-INSTITUTIONAL RETROSPECTIVE DESCRIPTIVE STUDY. Pediatr Blood Cancer. 2015; 62(1): 1-1

Arico M, Astigarraga I, Braier J, Donadieu J, Gadner H, Glogova E, et al. Lack of bone lesions at diagnosis is associated with inferior outcome in multisystem langerhans cell histiocytosis of childhood. Br J Haematol. 2015; 169(2): 241-248. DOI:10.1111/bjh.13271.

Mas N, Olaechea P, Palomar M, Alvarez Lerma F, Rivas R, Nuvials X, et al. Comparative analysis of patients admitted to Spanish Intensive Care Units due to medical and surgical disease. Med Intensiv. 2015; 39(5): 279-289. DOI:10.1016/j.medin.2014.07.006.

Gil Herrera J, Alonso Martinez M, Astigarraga I, Martin L, Martinez Rio I, Urrea R, et al. DOES GENETIC SUSCEPTIBILITY CONTRIBUTE TO LATE-ONSET PRESENTATION OF HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS?. Pediatr Blood Cancer. 2015; 62(1): 9-9

den Hoed M, Lopez E, te Winkel ML, Tissing W, de Rooij J, Gutierrez Camino A, et al. Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia. Pharmacogenomics J. 2015; 15(3): 248-254. DOI:10.1038/tpj.2014.63.

Paz N, Felipe Blanco I, Royo F, Zabala A, Guerra Merino I, Garcia Orad A, et al. Expression of the DYRK1A gene correlates with its 3D positioning in the interphase nucleus of Down syndrome cells. Chromosome Res. 2015; 23(2): 285-298. DOI:10.1007/s10577-015-9467-7.

Astigarraga I, Garcia Obregon S, Gil Herrera J, Perez Martinez A, Melo M, Mata C, et al. ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS (HLH) AND ASSOCIATED IMMUNODEFICIENCIES: CASES REPORTED IN SPAIN. Pediatr Blood Cancer. 2015; 62(3): 122-122

Ancin Arteaga I, Landeta E, Amarika I, Maruri N, Olivares N, Rinon M, et al. BABIES WITH ACUTE LEUKEMIA OF AMBIGIOUS LINEAGE AND T (4;11) (Q21;Q23)/ MLL-AF4 REARRANGEMENT. Haematologica. 2015; 100(4): 237-238

Aristizabal A, Merino S, Catediano E, Sasieta M, Araguees P, Navajas A. Clinical consequences of alpha-thalassemia in the basque country, Spain. Impact of neonatal screening. An Pediatr. 2015; 83(2): 85-88. DOI:10.1016/j.anpedi.2014.10.014.

Carlos Garcia Ruiz J, Olazabal I, Adan Pedroso RM, Lopez Soria L, Velasco Benito V, Antonio Sanchez Aparicio J, et al. Disseminated fusariosis and hematologic malignancies, a still devastating association. Report of three new cases. Rev Iberoam Micol. 2015; 32(3): 190-196. DOI:10.1016/j.riam.2014.11.003.

Martin Guerrero I, de Prado E, Ardanaz M, Martin Arruti M, Garcia Orad C, Guerra I, et al. Methylation of CpG sites in BCL2 major breakpoint region and the increase of BCL2/JH translocation with aging. Age. 2015; 37(5). DOI:10.1007/s11357-015-9834-5.

Adan R, Rubio R, Udaondo J, Lopez Macias O, Echebarria A, Lopez Almaraz R, et al. I131 META-IODOBENZYLGUANIDINE THERAPY IN CHILDREN WITH ADVANCE NEUROBLASTOMA. THE EXPERIENCE OF A HOSPITAL. Pediatr Blood Cancer. 2015; 62(4): 326-326

Lopez Almaraz R, Udaondo J, Rubio Rojas R, Zubiaur O, Garcia Ariza M, Echebarria Barona A, et al. IS IT REALLY USEFUL AS A PROGNOSTIC FACTOR THE ABSOLUTE LYMPHOCYTE COUNT AT THE END OF INDUCTION THERAPY IN IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA?. Pediatr Blood Cancer. 2015; 62(4): 254-255

Chellapandian D, Shaikh F, van den Bos C, Somers GR, Astigarraga I, Jubran R, et al. Management and Outcome of Patients With Langerhans Cell Histiocytosis and Single-Bone CNS-Risk Lesions: A Multi-Institutional Retrospective Study. Pediatr Blood Cancer. 2015; 62(12): 2162-2166. DOI:10.1002/pbc.25645.

Astigarraga I, Ceberio L, Gondra A, Adan R, Echebarria A, Canovas A, et al. LANGERHANS CELL HISTIOCYTOSIS (LCH) IN CHILDREN AND ADULTS: A COMPARATIVE STUDY OF 40 CASES. Pediatr Blood Cancer. 2015; 62(4): 299-300

Poetschger U, Arico M, Astigarraga I, Braier J, Donadieu J, Gadner H, et al. MULTISYSTEM LANGERHANS CELL HISTIOCYTOSIS (MS-LCH): PREDICTIVE VALUE OF SCORING SYSTEM BASED ON RISK-ORGAN INVOLVEMENT (RO) AT DIAGNOSIS. Pediatr Blood Cancer. 2015; 62(3): 136-136

Gutierrez Camino A, Martin Guerrero I, Lopez E, Bilbao Aldaiturriaga N, Garcia de Andoin N, Navajas A, et al. POLYMORPHISMS AND VINCRISTINE TOXICITY IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA. Pediatr Blood Cancer. 2015; 62(4): 247-248

Umerez M, Gutierrez Camino A, Martin Guerrero I, Lopez E, Bilbao Aldaiturriaga N, Pombar Gomez M, et al. POLYMORPHISMS IN MICRORNAS COULD AFFECT MTX CLEARANCE IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA. Pediatr Blood Cancer. 2015; 62(4): 247-247

Bilbao Aldaiturriaga N, Martin Guerrero I, Garcia Orad A. Research commentary regarding Savage et al. entitled "Genome-wide association study identifies two susceptibility loci for osteosarcoma". Cancer Genet. 2015; 208(11): 580-580. DOI:10.1016/j.cancergen.2015.09.003.

Pombar Gomez M, Lopez E, Martin Guerrero I, Garcia Orad A, de Pancorbo MM. Potential relationship between single nucleotide polymorphisms used in forensic genetics and diseases or other traits in European population (vol 129, pg 435, 2015). Int J Legal Med. 2015; 129(6): 1287-1287. DOI:10.1007/s00414-015-1227-x.

del Mar Andres M, Martin Guerrero I, Garcia Bragado F, Gonzalez Farre B, Balague O, Molina Garicano J, et al. Genetic profile of two pediatric aggressive lymphoma cases with relapse. Br J Haematol. 2015; 171(1, SI): 64-64

Salaverria I, Martin Guerrero I, Burkhardt B, Chassagne Clement C, Szczepanowski M, Bens S, et al. Non-leukemic pediatric mixed phenotype acute leukemia/lymphoma: genome-wide analysis and clinical outcome under treatment in a prospective clinical trial for lymphoblastic lymphoma. Br J Haematol. 2015; 171(1, SI): 67-68

Martin L, Alonso Martinez M, Delgado Mingo N, Astigarraga I, Ehl S, Ammann S, et al. PRF1 MUTATION VERSUS PERFORIN EXHAUSTION: TWO DIFFERENT SETTINGS FOR HLH DEVELOPMENT. Pediatr Blood Cancer. 2015; 62(3): 132-133

Oosterom N, Guttierez Camino A, Den Hoed M, Lopez E, Pluijm SMF, Pieters R, et al. CNOT1 Microrna Single Nucleotide Polymorphism (SNP) Determines the Occurrence of Methotrexate Related Mucositis in Pediatric Acute Lymphoblastic Leukemia. Blood. 2015; 126(23)

Salaverria I, Martin Garcia D, Lopez C, Clot G, Garcia Aragones M, Navarro A, et al. Detection of chromothripsis-like patterns with a custom array platform for chronic lymphocytic leukemia. Genes Chromosomes Cancer. 2015; 54(11): 668-680. DOI:10.1002/gcc.22277.

Estándares y recomendaciones de calidad y seguridad. Estándares y recomendaciones de calidad y seguridad. Guías de Práctica Clínica. 2015

Garcia Gutierrez S, Quintana JM, Baricot M, Bilbao A, Capelastegui A, Cilla Eguiluz CG, et al. Predictive factors of severe multilobar pneumonia and shock in patients with influenza. Emerg Med J. 2014; 31(4): 301-307. DOI:10.1136/emermed-2012-202081.

Lopez E, Gutierrez Camino A, Angeles Pinan M, Sanchez Toledo J, Javier Uriz J, Ballesteros J, et al. Pharmacogenetics of MicroRNAs and MicroRNAs Biogenesis Machinery in Pediatric Acute Lymphoblastic Leukemia. PLoS One. 2014; 9(3). DOI:10.1371/journal.pone.0091261.

Lannering B, Sabel M, Gustafsson G, Fleischhack G, Benesch M, Doz F, et al. PATTERNS AND TREATMENT OF RELAPSE AFTER STANDARD RISK MEDULLOBLASTOMA: A REPORT FROM THE HIT-SIOP PNET 4 TRIAL. Neuro-Oncology. 2014; 16(1): 79-79

Aurtenetxe O, Gaffar A, Gros L, Cruz O, Calvo C, Navajas A. FOLLOW UP OF SPANISH CHILDHOOD MEDULLOBLASTOMA. Neuro-Oncology. 2014; 16(1): 93-93

Gutierrez Camino A, Lopez E, Martin Guerrero I, Pinan MA, Garcia Miguel P, Sanchez Toledo J, et al. Noncoding RNA-related polymorphisms in pediatric acute lymphoblastic leukemia susceptibility. Pediatr Res. 2014; 75(6): 767-773. DOI:10.1038/pr.2014.43.

Bastida Lertxundi N, Lopez E, Angeles Pinan M, Puiggros A, Navajas A, Sole F, et al. Errors in the interpretation of copy number variations due to the use of public databases as a reference. Cancer Genet. 2014; 207(4): 164-167. DOI:10.1016/j.cancergen.2014.03.001.

Valles J, Martin Loeches I, Torres A, Diaz E, Seijas I, Jose Lopez M, et al. Epidemiology, antibiotic therapy and clinical outcomes of healthcare-associated pneumonia in critically ill patients: a Spanish cohort study. Intensive Care Med. 2014; 40(4): 572-581. DOI:10.1007/s00134-014-3239-2.

Kennedy C, Bull K, Chevignard M, Culliford D, Doerr HG, Doz F, et al. Quality of Survival and Growth in Children and Young Adults in the PNET4 European Controlled Trial of Hyperfractionated Versus Conventional Radiation Therapy for Standard-Risk Medulloblastoma. Int J Radiat Oncol Biol Phys. 2014; 88(2): 292-300. DOI:10.1016/j.ijrobp.2013.09.046.

Ruiz I, Martin Arruti M, Lopez E, Garcia Orad A. Lack of association between deficient mismatch repair expression and outcome in endometrial carcinomas of the endometrioid type. Gynecol Oncol. 2014; 134(1): 20-23. DOI:10.1016/j.ygyno.2014.04.053.

Morales Suarez Varela M, Gonzalez Candelas F, Astray J, Alonso J, Garin O, Castro A, et al. Pandemic Influenza A (H1N1) Infection in Pregnant and Nonpregnant Women in Spain (2009-2010). Jpn J Infect Dis. 2014; 67(3): 163-171. DOI:10.7883/yoken.67.163.

Martin Guerrero I, de Prado E, Lopez E, Ardanaz M, Carlos Vitoria J, Parada LA, et al. Methylation of the nonhomologous end joining repair pathway genes does not explain the increase of translocations with aging. Age. 2014; 36(6). DOI:10.1007/s11357-014-9730-4.

Lafuente Hidalgo M, García Besteiro M, Acedo Alonso Y, López Aríztegui MA, Navajas Gutierrez A. Revisión de cavernomatosis múltiple: a propósito de una familia. An Pediatr. 2014; 81(6). DOI:10.1016/j.anpedi.2014.03.002.

Astigarraga I, Olabarrieta N, Jesus Martinez Gonzalez M, Garcia Obregon S, Rosario Gonzalez Hermosa M, Zaldumbide L, et al. CENTRAL NERVOUS SYSTEM INVOLVEMENT AT THE ONSET OF GRISCELLI SYNDROME TYPE-2. Pediatr Blood Cancer. 2014; 61(11): 2130-2130

Astigarraga I, Echebarria A, Adan R, Garcia Ariza M, Lopez Almaraz R, Gil Anton J, et al. ONCOLOGIC EMERGENCIES THAT NEED INTENSIVE CARE AT DIAGNOSIS IN CHILDREN WITH CANCER. Pediatr Blood Cancer. 2014; 61(2): 391-391

Astigarraga I, Garcia Ariza M, Echebarria A, Echevarria Ecenarro J, Martinez Fernandez R, Adan R, et al. MULTIDISCIPLINARY APPROACH AND VISUAL ACUITY IN TREATED CASES OF OPTIC PATHWAY GLIOMAS. Pediatr Blood Cancer. 2014; 61(2): 279-280

Fernandez Teijeiro A, Hasenclever D, Echebarria A, Garrido C, Vivanco JL, Carbone A, et al. OUTCOME OF SPANISH PATIENTS OUTSIDE EURONET-PHL-C1. Pediatr Blood Cancer. 2014; 61(2): 201-201

Davi S, Minoia F, Pistorio A, Horne A, Consolaro A, Rosina S, et al. Performance of Current Guidelines for Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2014; 66(10): 2871-2880. DOI:10.1002/art.38769.

Nuvials X, Palomar M, Alvarez Lenna F, Olaechea P, Uriona S, Gracia MP, et al. SYSTEMIC INFLAMMATORY RESPONSE TO INFECTIONS IN PATIENTS ADMITTED TO ICU. PATIENT-RELATED RISK FACTORS. NB ENVINHELICS REGISTRY DATA. Intensive Care Med. 2014; 40(1): 85-86

Gutierrez Camino A, Lopez E, Martin Guerrero I, Garcia de Andoin N, Navajas A, Garcia Miguel P, et al. NEW SUSCEPTIBILITY MARKERS IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA: NON CODING RNAS. Pediatr Blood Cancer. 2014; 61(2): 258-258

Pombar Gomez M, Echebarria A, Bilbao Aldaiturriaga N, Pinan MA, Uriz J, Garcia Miguel P, et al. GENETIC VARIANTS IN VINCRISTINE TRANSPORTERS AS NEUROTOXICITY MARKERS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA. Pediatr Blood Cancer. 2014; 61(2): 172-172

Bilbao Aldaiturriaga N, Martin Guerrero I, Garcia Orad A. Letter regarding Wang et al. entitled "Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systematic review and meta-analysis". Tumour Biol. 2014; 35(7): 6179-6179. DOI:10.1007/s13277-014-1882-4.

Gutierrez Camino A, Lopez E, Garcia Orad A. SLC19A1 hot spot for MTX plasma concentration. Med Oncol. 2014; 31(10). DOI:10.1007/s12032-014-0204-4.

den Hoed M, Lopez E, Te Winkel ML, Tissing W, de Rooij J, Gutierrez Camino A, et al. Genetic and Metabolic Determinants of Methotrexate Induced Mucositis in Pediatric Acute Lymphoblastic Leukemia. Blood. 2014; 124(21)

Bilbao Aldaiturriaga N, Martin Guerrero I, Lopez E, Gutierrez Camino A, Patino Garcia A, Zalacain Diez M, et al. NON CODING RNAS AS NEW MARKERS OF SUSCEPTIBILITY TO OSTEOSARCOMA. Pediatr Blood Cancer. 2014; 61(2): 272-272

den Hoed M, Lopez E, te Winkel ML, Tissing W, de Rooij J, Gutierrez Camino A, et al. GENETIC AND METABOLIC DETERMINANTS OF METHOTREXATE INDUCED MUCOSITIS IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA. Pediatr Blood Cancer. 2014; 61(2): 140-141

Martin Guerrero I, Bilbao Aldaiturriaga N, Ascaiturrieta Z, Granado I, Patino Garcia A, Zalacain Diez M, et al. A NEW META-ANALYSIS IN MDM2 SHOWS NO ASSOCIATION BETWEEN RS2279744 AND RS1690916 AND RISK OF OSTEOSARCOMA: CRITICAL STUDY. Pediatr Blood Cancer. 2014; 61(2): 272-272

Lopez E, Martin Guerrero I, Gutierrez Camino A, Uriz J, Navajas A, Garcia Miguel P, et al. NON-CODING RNAS: A NEW FIELD IN THE PHARMACOGENETICS OF PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA. Pediatr Blood Cancer. 2014; 61(2): 257-257

Lopez-Lopez E, Martin-Guerrero I, Ballesteros J, Garcia-Orad A. A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia. Pharmacogenomics J. 2013;13:498-506. FI: 5,134(Q1)

Gutiérrez-Camino Á, López-López E, Martín-Guerrero I, Sánchez-Toledo J, García de Andoin N, Carboné Bañeres A, et al. Intron 3 of the ARID5B gene: a hot spot for acute lymphoblastic leukemia susceptibility. J Cancer Res Clin Oncol. 2013;139:1879-86. FI: 2,914(Q2)

Lopez-Lopez E, Gutierrez-Camino A, Martin-Guerrero I, Garcia-Orad A. Re: Novel Susceptibility Variants at 10p12.31-12.2 for Childhood Acute Lymphoblastic Leukemia in Ethnically Diverse Populations. JNCI-. Natl Cancer Inst. 2013;105:1512. FI: 14,336(Q1)

Astigarraga I, Garcia-Obregon S, Lillo M, Gonzalez S, Mata C, Vazquez MA, et al. Leishmaniasis and haemophagocytic lymphohistiocytosis (hlh) in spain: a diagnostic challenge. Pediatr Blood Cancer. 2013;60:71. FI: 2,353(Q1)

Astigarraga I, Lopez-Bastida J, Linertova R, Serrano-Aguilar P, Garcia-Obregon S, Alvarez-Garcia MR, et al. Social costs and health-related quality of life of patients with histiocytosis (burqol-rd project)-results of the pilot study in Spain. Pediatr Blood Cancer. 2013;60:71. FI: 2,353(Q1) (Meeting Abstract)

Cardesa Salzmann T, Alonso Garcia L, Celis V, Cruz Martinez O, Jou C, DeTorres C, et al. Impaired cytotoxic lymphocyte degranulation in a patient with langerhans cell histiocytosis complicated by a hemophagocytic syndrome. Pediatr Blood Cancer. 2013;60:73. FI: 2,353(Q1). (Meeting Abstract)

Donadieu J, Schaefer E, Astigarraga I, Haupt R, Minkov M, Price R. HISTIO NET - a reference network for the creation of online expert support for lch and associated syndromes. Pediatr Blood Cancer. 2013;60:75. FI: 2,353(Q1). (Meeting Abstract)

Urrea R, Astigarraga I, Fernandez-Teijeiro A, Rodriguez-Sainz C, Martinez-Rio I, Garcia-Obregon S, et al. FHL associated to the novel mutation G306D in pore forming (MACPF) domain of perforin. Pediatr Blood Cancer. 2013;60:83-4. FI: 2,353(Q1). (Meeting Abstract)

Astigarraga I, Martinez-Mugica O, Garcia-Martinez JM, Urberuaga A, Echebarria A, Adan R,  et al. Humoral immunity findings in acute lymphoblastic leukemia in children. Eur J Cancer. 2013;49:361. FI: 5,061(Q1). (Meeting Abstract)

Gutierrez-Camino A, Lopez-Lopez E, Martin-Guerrero I, Garcia-Miguel P, Sanchez-Toledo J, Carbone Baneres A, et al. New susceptibility markers of childhood acute lymphoblastic leukemia: microrna-related polymorphisms. Pediatr Blood Cancer. 2013;60:58-9. FI: 2,353(Q1). (Meeting Abstract)

López-López E, Echebarria A, Garcia de Andoin N, Garcia-Miguel P, Navajas A. Polymorphisms in genes of the vincristine pathway as neurotoxicity markers in pediatric acute lymphoblastic leukemia . Pediatr Blood Cancer. 2013;60:56. FI: 2,353(Q1). (Meeting Abstract)

Canete A, Yanez Y, Grau E, Palanca S, Perez G, Antuna MJ, et al. Impact of TH and DCX mRNAs detection in high-risk neuroblastoma patients' outcome. Eur J Cancer. 2013;49:356-7. FI: 5,061(Q1). (Meeting Abstract)

Bilbao-Aldaiturriaga N, López-López E, Martin-Guerrero I, Gutierrez-Camino A, Serrasesumaga L,  Zalacain-Diez M, et al. Pharmacogenetics of micrornas in osteosarcoma. Pediatr Blood Cancer. 2013;60:25-6. FI: 2,353(Q1). (Meeting Abstract)

Bilbao-Aldaiturriaga N, López-López E, Gutierrez-Camino A, Martin-Guerrero I, Serrasesumaga L,  Patino-Garcia A, et al. Microrna-related polymorphisms as osteosarcoma susceptibility markers. Pediatr Blood Cancer. 2013;60:85. FI: 2,353(Q1). (Meeting Abstract)

Martin-Guerrero I, Salaverria I, Burkhardt B, Szczepanowski M, Baudis M, Bens S, et al. Recurrent loss of heterozygosity in 1p36 associated with TNFRSF14 mutations in IRF4 translocation negative pediatric follicular lymphomas. Haematol-Hematol J. 2013;98:1237-41. FI: 5,935(Q1)

Gadner H, Minkov M, Grois N, Pötschger U, Thiem E, Aricò M, et al; Histiocyte Society. Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. Blood 2013;121:5006-14. FI: 9,060(Q1)

Launes C, García-García JJ, Martínez-Planas A, Moraga F, Soldevila N, Astigarraga I, et al; CIBERESP Cases and Controls in Pandemic Influenza Working Group. Clinical features of influenza disease in admitted children during the first postpandemic season and risk factors for hospitalization: a multicentre Spanish experience. Clin Microbiol Infect. 2013;19:157-62. FI: 4,578(Q1)

Haupt R, Minkov M, Astigarraga I, Schäfer E, Nanduri V, Jubran R, et al; Euro Histio Network. Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years. Pediatr Blood Cancer. 2013;60:175-84. FI: 2,353(Q1)

Lopez-Lopez E, Ballesteros J, Piñan MA, Sanchez de Toledo J, Garcia de Andoin N, Garcia-Miguel P, et al. Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia. Pharmacogenet Genomics. 2013;23:53-61. FI: 3,608(Q1)

Salaverria I, Martin-Guerrero I, Burkhardt B, Kreuz M, Zenz T, Oschlies I, et al. High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas. Gene Chromosomes Cancer. 2013;52:150-5. FI: 3,546(Q2)

Paz N, Zabala A, Royo F, García-Orad Á, Zugaza JL, Parada LA. Combined fluorescent-chromogenic in situ hybridization for identification and laser microdissection of interphase chromosomes. PLoS One. 2013;8:e60238. FI: 3,730(Q1)

Delgado-Rodriguez M, Castilla J, Godoy P, Martin V, Soldevila N, Alonso Jet al, CIBERESP Cases Controls Pandemic. Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain. Influenza Other Respir. Viruses. 2013;7:1336-42. FI: 1,471(Q4).

Moscardó Guilleme C, Fernández Delgado R, Sevilla Navarro J, Astigarraga Aguirre I, Rives Solà S, et al. Actualización del tratamiento con L-asparraginasa en Pediatría. An Pediatr (Barc). 2013;79:329. FI: 0,867(Q3).

Chellapandian D, Das R, Zelley K, Wiener SJ, Zhao H, Teachey DT, et al; EBV-HLH Rituximab Study Group. Treatment of Epstein Barr virus-induced haemophagocytic lymphohistiocytosis with rituximab-containing chemo-immunotherapeutic regimens. Br J Haematol. 2013;162:376-82. FI: 4,942(Q1).

Castilla J, Godoy P, Dominguez A, Martinez-Baz I, Astray J, Martin V, et al, CIBERESP Cases Controls Influenza. Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza. Clin Infect Dis. 2013;57:167-75. FI: 9,374(Q1)

Dominguez A, Castilla J, Godoy P, Delgado-Rodriguez M, Saez M, Soldevila N, et al, CIBERESP Cases Controls Pandemic. Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons. Human Vaccines Immunother. 2013;9:865-73. FI: 0,0(Q4).

Lassaletta A, Andión M, Garrido-Colino C, Gutierrez-Carrasco I, Echebarria-Barona A, Almazán F, et al. Situación actual de los adolescentes con cáncer en las unidades de hemato-oncología pediátrica españolas.. An Pediatr (Barc). 2013;78:268.e1-7. FI: 0,867(Q3).

Mayoral MJ, Alonso J, Garin O, Herrador Z, Astray J, Baricot M, et al, CIBERESP Cases Controls Pandemic I. Social factors related to the clinical severity of influenza cases in Spain during the A (H1N1) 2009 virus pandemic. BMC Public Health. 2013;13:118. FI: 2,076(Q2)

Tesis del grupo

Autor/a: Ane Larrabeiti Etxebarria. Título: "MikroRNAen potentziala B Zelula Handiko Linfoma Hedatsuaren diagnostiko, sailkapen eta pronostikoan". Directores/as: Dra. Elixabet López López, Dra. Angela Gutiérrez Camino.

Autor/a: Fco Javier Pilar Orive. Título: Identificación de un panel de marcadores proteicos en la fase inicial de la sepsis y su validación en una cohorte de pacientes pediátricos con sepsis grave. Director/a: Dra. Itziar Astigarraga, Dra. Susana García Obregón.

Autor/a: Olaia Aurtenetxe Saez. Título: "Estudio de mecanismos moleculares involucrados en el envejecimiento humano en un modelo experimental basado en células madre mesenquimales". Directores/as: Dra. Aurora Navajas Gutiérrez, Dra. Laura Zaldumbide Dueñas.

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